ReviewMolecular genetics and genomics : MGG2007
Public and private mechanisms of life extension in Caenorhabditis elegans.
Review in Molecular genetics and genomics : MGG, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- The impact of continuous calorie restriction and fasting on cognition in adults without eating disorders.Nutrition reviews · 2025Review
- Article
- Caloric restriction improves health and survival of rhesus monkeys.Nature communications · 2017Article
- Longevity and stress in Caenorhabditis elegans.Aging · 2011Review
- Nonhuman primate calorie restriction.Antioxidants & redox signaling · 2011Review
- ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.PLoS genetics · 2010Article
- Developmental biomarkers of aging in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- Article
- Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.BMC developmental biology · 2008Article
- Transcriptional (dys)regulation and aging in Caenorhabditis elegans.Genome biology · 2008Review
- Replicative aging in yeast: the means to the end.Annual review of cell and developmental biology · 2008Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Model organisms have been widely used to study the ageing phenomenon in order to learn about human ageing. Although the phylogenetic diversity between vertebrates and some of the most commonly used model systems could hardly be greater, several mechanisms of life extension are public (common characteristic in divergent species) and likely share a common ancestry. Dietary restriction, reduced IGF-signaling and, seemingly, reduced ROS-induced damage are the best known mechanisms for extending longevity in a variety of organisms. In this review, we summarize the knowledge of ageing in the nematode Caenorhabditis elegans and compare the mechanisms of life extension with knowledge from other model organisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.