ReviewCellular and molecular life sciences : CMLS2007
Neuroanatomy and neurochemistry of sleep.
Review in Cellular and molecular life sciences : CMLS, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- The relationship of sleep duration and insomnia to risk of hypertension incidence: a meta-analysis of prospective cohort studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2013Pooled it
- Maternal sleep deprivation reshapes offspring hippocampal development through a Trem2-centered microglial program revealed by single-nucleus and spatial transcriptomics.Molecular psychiatry · 2026Article
- Extraction Methods and Sedative-Hypnotic Effects of Total Flavonoids fromPharmaceuticals (Basel, Switzerland) · 2025Article
- NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model.iScience · 2025Article
- Evolution of canonical circadian clock genes underlies unique sleep strategies of marine mammals for secondary aquatic adaptation.PLoS genetics · 2025Article
- Oxygen consumption rate of flatworms under the influence of wake- and sleep-promoting neurotransmitters.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- Cortical development in the structural model and free energy minimization.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Why study sleep in flatworms?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Article
- Does EGFR Signaling Mediate Orexin System Activity in Sleep Initiation?International journal of molecular sciences · 2023Review
- Article
- A Review of Equine Sleep: Implications for Equine Welfare.Frontiers in veterinary science · 2022Review
- Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children.Journal of autism and developmental disorders · 2021Article
- Sleep Network Deterioration as a Function of Dim-Light-At-Night Exposure Duration in a Mouse Model.Clocks & sleep · 2020Article
- Article
- Acute and Chronic Sleep Deprivation-Related Changes in N-methyl-D-aspartate Receptor-Nitric Oxide Signalling in the Rat Cerebral Cortex with Reference to Aging and Brain Lateralization.International journal of molecular sciences · 2019Article
- Neuroendocrine Control of Sleep.Current topics in behavioral neurosciences · 2019Review
- Decreased brain serotonin turnover rate following administration of Sharbat-e-Ahmed Shah produces antidepressant and anxiolytic effect in rats.Metabolic brain disease · 2017Article
- Sleep and oligodendrocyte functions.Current sleep medicine reports · 2015Article
- Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts.Military Medical Research · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is regulated by homeostatic and circadian factors, and the regulation of sleep of mammals shares many molecular properties with the rest state of submammalian species. Several brain structures take part in waking: the basal forebrain, posterior and lateral hypothalamus, and nuclei in the tegmentum and pons. Active sleep mechanisms are located to the preoptic/anterior hypothalamic area. In addition to acetylcholine and monoamines, glutamate and hypocretin/orexin are important waking factors. Gamma-aminobutyric acid and several peptide factors, including cytokines, growth hormone-releasing hormone and prolactin, are related to sleep promotion. Adenosine is an important homeostatic sleep factor acting in basal forebrain and preoptic areas through A1 and A2A receptors. Prolonged waking activates inducible nitric oxide synthase in the basal forebrain, which through energy depletion causes adenosine release and recovery sleep. Numerous genes have been found differentially displayed in waking compared with sleep, and they relate to neural transmission, synaptic plasticity, energy metabolism and stress protection. The genetic background of a few sleep disorders has been solved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.