ArticleNeuron glia biology2006
Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp.
Article in Neuron glia biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Volume electron microscopy reveals oligodendrocyte axon selection patterns and spatial assembly of myelin and nodes.iScience · 2026Article
- A review focuses on a neglected and controversial component of SCI: myelin debris.Frontiers in immunology · 2024Review
- Sex Differences in the Effect of Alcohol Drinking on Myelinated Axons in the Anterior Cingulate Cortex of Adolescent Rats.Brain sciences · 2019Article
- Insights into the physiological role of CNS regeneration inhibitors.Frontiers in molecular neuroscience · 2015Review
- How do corticosteroids influence myelin genesis in the central nervous system?Neural regeneration research · 2014Article
- Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy.ACS chemical neuroscience · 2014Article
- Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
- Molecular mechanisms of node of Ranvier formation.Current opinion in cell biology · 2008Review
- Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury.Molecular and cellular neurosciences · 2008Article
- Netrin-1 is a novel myelin-associated inhibitor to axon growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Neurofascin assembles a specialized extracellular matrix at the axon initial segment.The Journal of cell biology · 2007Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 5 countries.
Funding
Abstract
The molecular mechanisms underlying the involvement of oligodendrocytes in formation of the nodes of Ranvier (NORs) remain poorly understood. Here we show that oligodendrocyte-myelin glycoprotein (OMgp) aggregates specifically at NORs. Nodal location of OMgp does not occur along demyelinated axons of either Shiverer or proteolipid protein (PLP) transgenic mice. Over-expression of OMgp in OLN-93 cells facilitates process outgrowth. In transgenic mice in which expression of OMgp is down-regulated, myelin thickness declines, and lateral oligodendrocyte loops at the node-paranode junction are less compacted and even join together with the opposite loops, which leads to shortened nodal gaps. Notably, each of these structural abnormalities plus modest down-regulation of expression of Na(+) channel alpha subunit result in reduced conduction velocity in the spinal cords of the mutant mice. Thus, OMgp that is derived from glia has distinct roles in regulating nodal formation and function during CNS myelination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.