ArticleThe Journal of investigative dermatology2007
Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice.
Article in The Journal of investigative dermatology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- C1q as a target molecule to treat human disease: What do mouse studies teach us?Frontiers in immunology · 2022Pooled it
- Innate Immune System Response to Burn Damage-Focus on Cytokine Alteration.International journal of molecular sciences · 2022Review
- A Plausible Role for Collectins in Skin Immune Homeostasis.Frontiers in immunology · 2021Review
- Point-of-care microfluidic devices for pathogen detection.Biosensors & bioelectronics · 2018Review
- Recombinant human mannose-binding lectin dampens human alveolar macrophage inflammatory responses to influenza A virus in vitro.Journal of leukocyte biology · 2014Article
- Article
- Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin.Frontiers in immunology · 2012Article
- Mannose-binding lectin binds to amyloid β protein and modulates inflammation.Journal of biomedicine & biotechnology · 2012Article
- Topical application effect of the isolectin hydrogel (Cramoll 1,4) on second-degree burns: experimental model.Journal of biomedicine & biotechnology · 2012Article
- Mannose-binding lectin and the balance between immune protection and complication.Expert review of anti-infective therapy · 2011Review
- Investigating the humoral immune response in chronic venous leg ulcer patients colonised with Pseudomonas aeruginosa.International wound journal · 2011Article
- Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin.Biochemical pharmacology · 2011Article
- Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection.BMC immunology · 2010Article
- A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus.The Journal of biological chemistry · 2010Article
- Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review.Clinical and molecular allergy : CMA · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Burn injury destroys skin, the second largest innate immune organ in the body, and triggers chaotic immune and inflammatory responses. The pattern recognition molecule, mannan-binding lectin (MBL), plays an important role in the first-line host defense against infectious agents. MBL initiates the lectin complement pathway and acts as an opsonin. Recent studies suggest that MBL also modulates inflammatory responses. We report that local responses after burn in MBL null mice differ from those found in wild-type (WT) mice in the following important biological markers: spontaneous eschar separation, thinned epidermis and dermis, upregulation of soluble factors including cytokines, chemokines, cell adhesion molecules, a growth factor-binding protein, and matrix metalloproteinases. Mice lacking C1q, C4, or C3 did not show the lack of eschar separation seen in MBL null-burn phenotype. These findings implicate MBL as an important molecule in the maintenance of the homeostatic balance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.