ArticleJournal of perinatology : official journal of the California Perinatal Association2007
Comparison of glyburide and insulin for the management of gestational diabetics with markedly elevated oral glucose challenge test and fasting hyperglycemia.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Can glyburide be advocated over subcutaneous insulin for perinatal outcomes of women with gestational diabetes? A systematic review and meta-analysis.Archives of gynecology and obstetrics · 2020Pooled it
- Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis.PloS one · 2017Pooled it
- Feto-placental endothelial dysfunction in Gestational Diabetes Mellitus under dietary or insulin therapy.BMC endocrine disorders · 2023Article
- Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors.Frontiers in cardiovascular medicine · 2022Review
- Pharmacological Management of Gestational Diabetes Mellitus.Current diabetes reports · 2016Review
- Comparison of Glibenclamide and Insulin on Neonatal Outcomes in Pregnant Women with Gestational Diabetes.International journal of preventive medicine · 2016Article
- Using oral agents to manage gestational diabetes: what have we learned?Current diabetes reports · 2015Review
- Oral hypoglycemic agents: do the ends justify the means?Maternal health, neonatology and perinatology · 2015Review
- Gestational diabetes mellitus: challenges in diagnosis and management.Journal of diabetes and metabolic disorders · 2015Article
- Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States, 2000-2011.Obstetrics and gynecology · 2014Article
- Diabetes and pregnancy: an endocrine society clinical practice guideline.The Journal of clinical endocrinology and metabolism · 2013Article
- The management of gestational diabetes.Vascular health and risk management · 2009Review
- Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care.Diabetes care · 2008Article
- Gestational diabetes mellitus: what is the optimal treatment modality?Journal of perinatology : official journal of the California Perinatal Association · 2007Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the effectiveness of glyburide and insulin for the treatment of Gestational diabetes mellitus (GDM) in women who had OGCT >or=200 mg/dl and fasting hyperglycemia. STUDY
designA retrospective study was performed among a subset of women treated with glyburide or insulin for GDM from 1999 to 2002 with an OGCT >or=200 mg/dl and pretreatment fasting plasma glucose >or=105 mg/dl. Exclusion criteria included pretreatment fasting >or=140 mg/dl, gestational age >or=34 weeks and multiple gestation. Maternal and neonatal outcomes were assessed. Statistical methods included bivariate and multivariable logistic regression analyses.
resultsIn 1999 to 2000, 78 women were treated with insulin; in 2001 to 2002, 44 of 69 (64%) received glyburide. There were no statistically significant differences between the two groups with regards to mean OGCT (230+/-25 vs 223+/-23 mg/dl, P=0.07) and mean pretreatment fasting (120+/-10 vs 119+/-11 mg/dl, P=0.45). Seven women (16%) failed glyburide. Women in the insulin group were younger (31.5+/-5.8 vs 35.2+/-4.7 years, P<0.001) and had a higher mean BMI (32.4+/-6.4 vs 29.1+/-5.8 kg/m(2), P=0.003) compared to glyburide group. There were no significant differences in birth weight (3524+/-548 vs 3420+/-786 g, P=0.65), macrosomia (19 vs 23%, P=0.65), pre-eclampsia (12 vs 11%, P=0.98) or cesarean delivery (39 vs 46%, P=0.45). Neonates in the glyburide group were diagnosed more frequently with hypoglycemia (34 vs 14%, P=0.01). When controlled for confounders, macrosomia was found to be associated with glyburide treatment (OR 3.5, 95% CI 1.1 to 11.4).
conclusionIn women with GDM who had a markedly elevated OGCT and fasting hyperglycemia, glyburide achieved similar birth weights and delivery outcomes but was associated with an increased risk of macrosomia. The possible increased risk of neonatal hypoglycemia in the glyburide group warrants further investigation.
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