Trial reportAmerican journal of respiratory and critical care medicine2007
Genetic determinants of emphysema distribution in the national emphysema treatment trial.
Trial report in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.The European respiratory journal · 2014Pooled it
- Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.American journal of respiratory and critical care medicine · 2011Trial
- Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency.Respiratory research · 2009Trial
- Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision.American journal of respiratory and critical care medicine · 2022Article
- Therapeutic Potential of Small Molecules Targeting Oxidative Stress in the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Comprehensive Review.Molecules (Basel, Switzerland) · 2022Review
- Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop.Circulation. Cardiovascular imaging · 2021Article
- Imbalance Between Injury and Defense in the COPD Emphysematous Phenotype.Frontiers in medicine · 2021Review
- Lung cancer and obstructive lung disease in never smokers.Journal of thoracic disease · 2020Article
- Celebration of the 50-Year Anniversary of the National Heart, Lung, and Blood Institute Division of Lung Diseases: A Half-Century of Landmark Clinical Trials.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Review
- Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity.BMC pulmonary medicine · 2019Article
- Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers.Academic radiology · 2019Article
- Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers.Academic radiology · 2019Article
- RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia.BMC genomics · 2019Article
- Influence of Emphysema and Air Trapping Heterogeneity on Pulmonary Function in Patients with COPD.International journal of chronic obstructive pulmonary disease · 2019Article
- Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.Chest · 2018Article
- Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.American journal of respiratory and critical care medicine · 2017Article
- Genetic polymorphism in matrix metalloproteinase-9 and transforming growth factor-β1 and susceptibility to combined pulmonary fibrosis and emphysema in a Chinese population.The Kaohsiung journal of medical sciences · 2017Article
- A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.American journal of respiratory and critical care medicine · 2015Article
- Regional Emphysema of a Non-Small Cell Tumor Is Associated with Larger Tumors and Decreased Survival Rates.Annals of the American Thoracic Society · 2015Article
- Clinically relevant subgroups in COPD and asthma.European respiratory review : an official journal of the European Respiratory Society · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 1 country.
Funding
Abstract
rationaleComputed tomography (CT) scanning of the lung may reduce phenotypic heterogeneity in defining subjects with chronic obstructive pulmonary disease (COPD), and allow identification of genetic determinants of emphysema severity and distribution.
objectivesWe sought to identify genes associated with CT scan distribution of emphysema in individuals without alpha1-antitrypsin deficiency but with severe COPD.
methodsWe evaluated baseline CT densitometry phenotypes in 282 individuals with emphysema enrolled in the Genetics Ancillary Study of the National Emphysema Treatment Trial, and used regression models to identify genetic variants associated with emphysema distribution. MEASUREMENTS AND MAIN
resultsEmphysema distribution was assessed by two methods--assessment by radiologists and by computerized density mask quantitation, using a threshold of -950 Hounsfield units. A total of 77 polymorphisms in 20 candidate genes were analyzed for association with distribution of emphysema. GSTP1, EPHX1, and MMP1 polymorphisms were associated with the densitometric, apical-predominant distribution of emphysema (p value range = 0.001-0.050). When an apical-predominant phenotype was defined by the radiologist scoring method, GSTP1 and EPHX1 single-nucleotide polymorphisms were found to be significantly associated. In a case-control analysis of COPD susceptibility limited to cases with densitometric upper-lobe-predominant cases, the EPHX1 His139Arg single-nucleotide polymorphism was associated with COPD (p = 0.005).
conclusionsApical and basal emphysematous destruction appears to be influenced by different genes. Polymorphisms in the xenobiotic enzymes, GSTP1 and EPHX1, are associated with apical-predominant emphysema. Altered detoxification of cigarette smoke metabolites may contribute to emphysema distribution, and these findings may lead to further insight into genetic determinants of emphysema.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.