ArticleAnnals of the rheumatic diseases2007
Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor.
Article in Annals of the rheumatic diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Vitamin D Metabolic Pathway Components in Orthopedic Patientes-Systematic Review.International journal of molecular sciences · 2022Pooled it
- The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?Clinical orthopaedics and related research · 2019Pooled it
- Risk factors for revision of primary total hip arthroplasty: a systematic review.BMC musculoskeletal disorders · 2012Pooled it
- Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsPooled it
- Prosthesis-Related Risk Factors for Trunnionosis: A Comprehensive Literature Review.Clinics in orthopedic surgery · 2026Review
- Genomic Insights into Host Susceptibility to Periprosthetic Joint Infections: A Comprehensive Literature Review.Microorganisms · 2024Review
- Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis.Cardiovascular toxicology · 2024Observational
- Single nucleotide polymorphisms in the development of osteomyelitis and prosthetic joint infection: a narrative review.Frontiers in immunology · 2024Review
- Role of Biomarkers in Periprosthetic Joint Infections.Diagnostics (Basel, Switzerland) · 2022Review
- Genetic Polymorphisms Associated with Perioperative Joint Infection following Total Joint Arthroplasty: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2022Review
- Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy.Bioactive materials · 2022Article
- Exosome: Function and Application in Inflammatory Bone Diseases.Oxidative medicine and cellular longevity · 2021Review
- What the Surgeon Can Do to Reduce the Risk of Trunnionosis in Hip Arthroplasty: Recommendations from the Literature.Materials (Basel, Switzerland) · 2020Review
- Development of an Integrated Platform Using Multidisciplinary Real-World Data to Facilitate Biomarker Discovery for Medical Products.Clinical and translational science · 2020Article
- Influence of single nucleotide polymorphisms (SNPs) in genetic susceptibility towards periprosthetic osteolysis.Genes & genomics · 2019Review
- The clinical, radiological, microbiological, and molecular profile of the skin-penetration site of transfemoral amputees treated with bone-anchored prostheses.Journal of biomedical materials research. Part A · 2017Article
- Reduction of serum 25-hydroxyvitamin D concentrations with intravenous lipid emulsion in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2016Article
- Genetic susceptibility of early aseptic loosening after total hip arthroplasty: the influence of TIMP-1 gene polymorphism on Chinese Han population.Journal of orthopaedic surgery and research · 2014Article
- Do genetic susceptibility, Toll-like receptors, and pathogen-associated molecular patterns modulate the effects of wear?Clinical orthopaedics and related research · 2014Review
- Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism.Diagnostic pathology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMatrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses to such stimuli may be dictated by genetic variation.
objectiveTo study the effect of single-nucleotide polymorphisms (SNPs) within these candidate genes.
methodsA case-control study of the MMP1, IL6 and VDR genes was performed for possible association with deep sepsis or aseptic loosening. All cases included in the study were Caucasian patients with osteoarthritis who had received a cemented Charnley total hip arthroplasty (THA) and polyethylene acetabular cup. Cases consisted of 91 patients with early aseptic loosening and 71 patients with microbiological evidence of deep infection on surgery. Controls consisted of 150 patients with THAs that were clinically asymptomatic for over 10 years and showed no radiographic features of aseptic loosening. DNA samples from all individuals were genotyped using Taqman allelic discrimination.
resultsThe C allele (p = 0.001; OR = 3.27; 95% CI 2.21 to 4.83) and C/C genotype (p = 0.001) for the MMP1 SNP were highly associated with aseptic failure when compared with controls. No statistically significant relationships were found between aseptic loosening and the MMP2, MMP4, IL6 -174 or VDRL SNPs. The T allele (p = 0.007; OR = 1.76; 95% CI 1.16 to 2.66) and T/T genotype (p = 0.028) for VDR-T were statistically associated with osteolysis owing to deep infection as compared with controls. No statistically significant relationship was found between septic failure and any of the other SNPs examined in this study.
conclusionsAseptic loosening and possibly deep infection of THR may be due to the genetic influence of candidate susceptibility genes. SNP markers may serve as predictors of implant survival and aid in pharmacogenomic prevention of THR failure.
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Registered trials
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