ArticleThe Journal of physiology2007
Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjects.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- The Temporal Profiles of Changes in Nerve Excitability Indices in Familial Amyloid Polyneuropathy.PloS one · 2015Trial
- The voltage dependence of I(h) in human myelinated axons.The Journal of physiology · 2012Trial
- Emergent technologies in clinical neurophysiology to study the neuromuscular system: IFCN handbook chapter.Clinical neurophysiology practice · 2026Review
- Nerve excitability test and lead toxicity: a case-control study.Journal of occupational medicine and toxicology (London, England) · 2023Article
- Altered flexor carpi radialis motor axon excitability properties after cerebrovascular stroke.Frontiers in neurology · 2023Article
- Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- Peripheral axonal excitability in hemiplegia related to subacute strokeTurkish journal of medical sciences · 2020Article
- HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons.eLife · 2019Article
- From Perception Threshold to Ion Channels-A Computational Study.Biophysical journal · 2019Article
- IThe Journal of physiology · 2019Article
- Hyperpolarization-activated cyclic-nucleotide-gated channels potentially modulate axonal excitability at different thresholds.Journal of neurophysiology · 2017Article
- Motor Unit Activity during Fatiguing Isometric Muscle Contraction in Hemispheric Stroke Survivors.Frontiers in human neuroscience · 2017Article
- In vivo impact of presynaptic calcium channel dysfunction on motor axons in episodic ataxia type 2.Brain : a journal of neurology · 2016Article
- Excitability properties of motor axons in adults with cerebral palsy.Frontiers in human neuroscience · 2015Article
- Peripheral nerve axonal excitability studies: expanding the neurophysiologist's armamentarium.Cerebellum & ataxias · 2015Article
- Transynaptic changes evident in peripheral axonal function after acute cerebellar infarct.Cerebellum (London, England) · 2014Article
- Voluntary Activation is Reduced in Both the More- and Less-Affected Upper Limbs after Unilateral Stroke.Frontiers in neurology · 2014Article
- IH activity is increased in populations of slow versus fast motor axons of the rat.Frontiers in human neuroscience · 2014Article
- Single motor unit firing rate after stroke is higher on the less-affected side during stable low-level voluntary contractions.Frontiers in human neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated whether there are changes in the excitability of motor axons in peripheral nerves of patients with corticospinal lesions, reflecting plasticity of the motoneuron due to altered descending drives and/or changes in afferent feedback. The excitability of motor and sensory axons in peripheral nerves of the affected limb of 11 patients with unilateral hemiparesis due to stroke was compared with that for the unaffected limbs and with data for 12 age-matched controls. There was significantly less accommodation to hyperpolarizing currents in motor axons on the affected side. There were small differences between the data for the unaffected side and that of the control subjects but these were not statistically significant. Other findings indicate that there was no change in resting membrane potential. There was no comparable alteration in the excitability of sensory axons. The changes in response of motor axons to hyperpolarizing currents could be reproduced in a computer model of the human motor axon by reducing the hyperpolarization-activated conductance, IH, by 30% and the quantitatively small leak conductance by 77%. The data for the uninvolved side matched the data for control subjects best when IH was increased. These findings are consistent with modulation of IH by activity. They demonstrate a change in the biophysical properties of motor axons not directly affected by the pathology and synaptically remote from the lesion, and have implications for 'trans-synaptic' changes in central nervous system pathways. In human subjects studies of motor axon properties may allow insight into processes affecting the motoneuron.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.