ArticleThe Journal of physiology2007
Dynamics of the readily releasable pool during post-tetanic potentiation in the rat calyx of Held synapse.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Presynaptic Mitochondria Communicate With Release Sites for Spatio-Temporal Regulation of Exocytosis at the Motor Nerve Terminal.Frontiers in synaptic neuroscience · 2022Article
- Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation.Molecular metabolism · 2020Article
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- Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.Neuroscience bulletin · 2019Article
- Erythropoietin Induces Homeostatic Plasticity at Hippocampal Synapses.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Molecular Mechanisms of Short-Term Plasticity: Role of Synapsin Phosphorylation in Augmentation and Potentiation of Spontaneous Glutamate Release.Frontiers in synaptic neuroscience · 2018Article
- A single episode of high intensity sound inhibits long-term potentiation in the hippocampus of rats.Scientific reports · 2017Article
- Dynamin-1 deletion enhances post-tetanic potentiation and quantal size after tetanic stimulation at the calyx of Held.The Journal of physiology · 2017Article
- Plasticity-dependent, full detonation at hippocampal mossy fiber-CA3 pyramidal neuron synapses.eLife · 2016Article
- Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration.The Journal of cell biology · 2014Article
- Article
- Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity.Neuron · 2014Article
- Theoretical models of synaptic short term plasticity.Frontiers in computational neuroscience · 2013Article
- Article
- Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Ethanol modulation of synaptic plasticity.Neuropharmacology · 2011Review
- Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Developmental changes in short-term plasticity at the rat calyx of Held synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held.Neuron · 2011Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The size of the readily releasable pool (RRP) of vesicles was measured in control conditions and during post-tetanic potentiation (PTP) in a large glutamatergic terminal called the calyx of Held. We measured excitatory postsynaptic currents evoked by a high frequency train of action potentials in slices of 4-11-day-old rats. After a tetanus the cumulative release during such a train was enlarged by approximately 50%, indicating that the size of the RRP was increased. The amount of enhancement depended on the duration and frequency of the tetanus and on the age of the rat. After the tetanus, the size of the RRP decayed more slowly (t(1/2)=10 versus 3 min) back to control values than the release probability. This difference was mainly due to a very fast initial decay of the release probability, which had a time constant compatible with an augmentation phase (tau approximately 30 s). The overall decay of PTP at physiological temperature was not different from room temperature, but the increase in release probability (P(r)) was restricted to the first minute after the tetanus. Thereafter PTP was dominated by an increase in the size of the RRP. We conclude that due to the short lifetime of the increase in release probability, the contribution of the increase in RRP size during post-tetanic potentiation is more significant at physiological temperature.
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