ArticleThe Journal of physiology2007
Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Enteric nervous system and inflammatory bowel disease.Gastroenterology report · 2026Review
- Obesity-Related Oxidative Stress and Antioxidant Properties of Natural Compounds in the Enteric Nervous System: A Literature Overview.Antioxidants (Basel, Switzerland) · 2026Review
- The enteric nervous system.Physiological reviews · 2023Review
- Methods to Study the Myenteric Plexus of Rat Small Intestine.Cellular and molecular neurobiology · 2023Article
- The α isoform of cGMP-dependent protein kinase 1 (PKG1α) is expressed and functionally important in intrinsic primary afferent neurons of the guinea pig enteric nervous system.Neurogastroenterology and motility · 2021Article
- The enteric nervous system in gastrointestinal disease etiology.Cellular and molecular life sciences : CMLS · 2021Review
- Recommendations for evaluation of bladder and bowel function in pre-clinical spinal cord injury research.The journal of spinal cord medicine · 2020Review
- To learn, to remember, to forget-How smart is the gut?Acta physiologica (Oxford, England) · 2020Review
- Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response.Psychopharmacology · 2019Review
- Enteric Neuronal Regulation of Intestinal Inflammation.Trends in neurosciences · 2016Review
- Colitis-induced neuroplasticity disrupts motility in the inflamed and post-inflamed colon.The Journal of clinical investigation · 2015Review
- Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon.The Journal of physiology · 2013Article
- The roles of purinergic signaling during gastrointestinal inflammation.Current opinion in pharmacology · 2012Review
- Quantified terminal ileal motility during MR enterography as a potential biomarker of Crohn's disease activity: a preliminary study.European radiology · 2012Article
- Neuronal activation and plasticity in Schistosoma mansoni infected mice.Saudi journal of biological sciences · 2012Article
- Plasticity of mouse enteric synapses mediated through endocannabinoid and purinergic signaling.Neurogastroenterology and motility · 2012Article
- Morphological and functional changes in guinea-pig neurons projecting to the ileal mucosa at early stages after inflammatory damage.The Journal of physiology · 2011Article
- The traditional antidiarrheal remedy, Garcinia buchananii stem bark extract, inhibits propulsive motility and fast synaptic potentials in the guinea pig distal colon.Neurogastroenterology and motility · 2010Article
- Neuroinflammation in inflammatory bowel disease.Journal of neuroinflammation · 2010Review
- All ahead stop! How intestinal motility adapts to cope with inflammation induced ulceration.The Journal of physiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The purpose of this study was to investigate the pre- and postsynaptic mechanisms that contribute to synaptic facilitation in the myenteric plexus of the trinitrobenzene sulphonic acid-inflamed guinea-pig distal colon. Intracellular recordings of evoked fast excitatory postsynaptic potentials (fEPSPs) in myenteric S neurons were evaluated, and the density of synaptic terminals was morphometrically analysed by transmission electron microscopy. In inflamed tissue, fEPSPs were reduced to control levels by the protein kinase A (PKA) inhibitor, H89, but H89 did not affect the fEPSPs in control tissue. This PKA activation in inflamed tissue did not appear to involve 5-HT(4) receptors because the antagonist/inverse agonist, GR 125487, caused comparable decreases of fEPSPs in both tissues. Inhibition of BK channels with iberiotoxin did not alter the fEPSPs in inflamed tissue, but increased the fEPSPs in control tissue to the amplitude detected in inflamed tissue. During trains of stimuli, run-down of EPSPs was less extensive in inflamed tissue and there was a significant increase in the paired pulse ratio. Depolarizations in response to exogenous neurotransmitters were not altered in inflamed tissue. These inflammation-induced changes were not accompanied by alterations in the pharmacological profile of EPSPs, and no changes in synaptic density were detected by electron microscopy. Collectively, these data indicate that synaptic facilitation in the inflamed myenteric plexus involves a presynaptic increase in PKA activity, possibly involving an inhibition of BK channels, and an increase in the readily releasable pool of synaptic vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.