ArticleThe Journal of physiology2007
Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 108 citations in OpenAlex.
- Amplification of endothelium-dependent vasodilatation in contracting human skeletal muscle: role of KThe Journal of physiology · 2019Trial
- Quantitative analysis of the postcontractile blood-oxygenation-level-dependent (BOLD) effect in skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Trial
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- Functional implications of microvascular heterogeneity for oxygen uptake and utilization.Physiological reports · 2022Review
- Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation.Frontiers in physiology · 2022Review
- Inward Rectifier Potassium Channels: Membrane Lipid-Dependent Mechanosensitive Gates in Brain Vascular Cells.Frontiers in cardiovascular medicine · 2022Review
- Regulation of muscle potassium: exercise performance, fatigue and health implications.European journal of applied physiology · 2021Review
- Effect of obesity on cardiovascular responses to submaximal treadmill exercise in adult males.Journal of family medicine and primary care · 2020Article
- KThe Journal of physiology · 2020Article
- Physiological Impact and Clinical Relevance of Passive Exercise/Movement.Sports medicine (Auckland, N.Z.) · 2019Review
- Recovery of blood flow regulation in microvascular resistance networks during regeneration of mouse gluteus maximus muscle.The Journal of physiology · 2019Article
- Elevated extracellular potassium prior to muscle contraction reduces onset and steady-state exercise hyperemia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Inhibition of NaThe Journal of physiology · 2018Article
- Neuropeptide Y1 and alpha-1 adrenergic receptor-mediated decreases in functional vasodilation in gluteus maximus microvascular networks of prediabetic mice.Physiological reports · 2018Article
- Capillary response to skeletal muscle contraction: evidence that redundancy between vasodilators is physiologically relevant during active hyperaemia.The Journal of physiology · 2018Article
- Absence of compensatory vasodilation with perfusion pressure challenge in exercise: evidence for and implications of the noncompensator phenotype.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Hyper-Oxygenation Attenuates the Rapid Vasodilatory Response to Muscle Contraction and Compression.Frontiers in physiology · 2018Article
- Rapid versus slow ascending vasodilatation: intercellular conduction versus flow-mediated signalling with tetanic versus rhythmic muscle contractions.The Journal of physiology · 2017Article
- Skeletal muscle contraction-induced vasodilation in the microcirculation.Journal of exercise rehabilitation · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid onset of vasodilatation within seconds of a single contraction suggests that the vasodilators involved may be products of skeletal muscle activation, such as potassium (K(+)). To test the hypothesis that K(+) was in part responsible for the rapid dilatation produced by muscle contraction we stimulated four to five skeletal muscle fibres in the anaesthetized hamster cremaster preparation in situ and measured the change in diameter of arterioles at a site of overlap with the stimulated muscle fibres before and after a single contraction stimulated over a range of stimulus frequencies (4, 10, 20, 30, 40, 60 and 80 Hz; 250 ms train duration). Muscle fibres were stimulated in the absence and presence of an inhibitor of a source of K(+), the voltage dependent K(+) channel inhibitor 3,4-diaminopyridine (DAP, 3 x 10(-4) M) and inhibitors of the K(+) dilatory signal transduction pathway, either a Na(+) K(+)-ATPase inhibitor (ouabain; 10(-4) M) or an inward rectifying K(+) channel inhibitor (barium chloride, BaCl(2); 5 x 10(-5) M). We observed significant inhibitions of the rapid dilatation at all stimulus frequencies with each inhibitor. The dilatory event at 4 s was significantly inhibited at all stimulus frequencies by an average of 65.7 +/- 3.6%, 58.8 +/- 6.1% and 64.4 +/- 2.1% in the presence DAP, ouabain and BaCl(2), respectively. These levels of inhibition did not correlate with non-specific changes in force generation by skeletal muscle measured in vitro. Therefore, our data support that K(+) is involved in the rapid dilatation in response to a single muscle contraction across a wide range of stimulus frequencies.
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