ArticleExperimental neurology2007
Neurokinins enhance excitability in capsaicin-responsive DRG neurons.
Article in Experimental neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesia.bioRxiv : the preprint server for biology · 2026Article
- Gaussian white noise stimulation as an alternative method to excite sensory neurons.Frontiers in pharmacology · 2025Article
- Myocardial infarction with a preserved ejection fraction-the impaired function of the cardio-renal baroreflex.Frontiers in physiology · 2023Article
- Responsiveness of afferent renal nerve units in renovascular hypertension in rats.Pflugers Archiv : European journal of physiology · 2021Article
- Studying human nociceptors: from fundamentals to clinic.Brain : a journal of neurology · 2021Review
- Neurogenic substance P-influences on action potential production in afferent neurons of the kidney?Pflugers Archiv : European journal of physiology · 2021Article
- Article
- A-Type KFrontiers in molecular neuroscience · 2018Review
- Morphological and functional diversity of first-order somatosensory neurons.Biophysical reviews · 2017Review
- Accelerated onset of the vesicovesical reflex in postnatal NGF-OE mice and the role of neuropeptides.Experimental neurology · 2016Article
- Characteristics of dorsal root ganglia neurons sensitive to Substance P.Molecular pain · 2014Article
- Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Common theme for drugs effective in overactive bladder treatment: inhibition of afferent signaling from the bladder.International journal of urology : official journal of the Japanese Urological Association · 2013Review
- Activation of neurokinin-1 receptors increases the excitability of guinea pig dorsal root ganglion cells.The Journal of pharmacology and experimental therapeutics · 2012Article
- Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- An antinociceptive role for substance P in acid-induced chronic muscle pain.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male rats.The Journal of pharmacology and experimental therapeutics · 2010Article
- Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons.Experimental neurology · 2009Article
- Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium.The Journal of physiology · 2009Article
- Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats.Psychopharmacology · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neurokinins released by capsaicin-responsive (C-R) dorsal root ganglia neurons (DRG) may control firing in these neurons by an autofeedback mechanism. Here we used patch clamp techniques to examine the effects of neurokinins on firing properties of dissociated DRG neurons of male rats. In C-R neurons that generated only a few action potentials (APs, termed phasic) in response to long depolarizing current pulses (600 ms), substance P (SP, 0.5 microM) lowered the AP threshold by 11.0+/-0.3 mV and increased firing from 1.1+/-0.7 APs to 5.2+/-0.6 APs. In C-R tonic neurons that fire multiple APs, SP elicited smaller changes in AP threshold (6.0+/-0.1 mV reduction) and the number of APs (11+/-1 vs. 9+/-1 in control). The effects of SP were similar to the effect of heteropodatoxin II (0.05 microM) or low concentrations of 4-aminopyridine (50 microM) that block A-type K(+) currents. A selective NK(2) agonist, [betaAla(8)]-neurokinin A (4-10) (0.5 microM), mimicked the effects of SP. The effects of SP in C-R phasic neurons were fully reversed by an NK(2) receptor antagonist (MEN10376, 0.5 microM) but only partially by a protein kinase C (PKC) inhibitor (bisindolylmaleimide, 0.5 microM). An NK(3)-selective agonist ([MePhe(7)]-neurokinin B, 0.5 microM), an NK(1)-selective agonist ([Sar(9), Met(11)]-substance P, 0.5 microM) or activation of PKC with phorbol 12,13-dibutyrate (0.5 microM) did not change firing. Our data suggest that the excitability of C-R phasic afferent neurons is increased by activation of NK(2) receptors and intracellular signaling mediated only in part by PKC.
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