ArticleProceedings of the National Academy of Sciences of the United States of America1992
Distribution of interspersed repeats (Alu and Kpn) on NotI restriction fragments of human chromosome 21.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- SINE and LINE within human centromeres.Journal of molecular evolution · 1996Article
- Pig genome analysis: differential distribution of SINE and LINE sequences is less pronounced than in the human and mouse genomes.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Assignment of Alu-repetitive sequences to large restriction fragments from human chromosomes 6 and 22.Molecular biology reports · 1995Article
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5 authors.
Funding
Abstract
Interspersed repeated sequences (Alu and Kpn) were used as probes to detect a set of Not I restriction fragments of human chromosome 21 from the hybrid cell line WAV17. Forty different Not I fragments, ranging in size from less than 0.05 megabase (Mb) to 7.0 Mb, were identified. The total length of these fragments was 47.3 Mb. This length provides an estimate of the minimum size of the chromosome and a minimum number of fragments to be ordered to create a complete restriction map. The average length Not I fragment is 1.2 Mb. Alu and Kpn fragments are not always coincident: a 2.9-Mb fragment is detected with Kpn but not with Alu, and 13 fragments, ranging from less than 0.05 Mb to 5.6 Mb, are detected with Alu but not with Kpn; the 26 remaining fragments, covering 75% (35.3 Mb) of the total length, are detected with both repetitive probes. The presence of so many noncoincident fragments and the high variation of the hybridization signal intensities of the fragments suggest a very nonuniform distribution of Kpn and Alu repeats.
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