ArticleBMC microbiology2007
The capsule polysaccharide structure and biogenesis for non-O1 Vibrio cholerae NRT36S: genes are embedded in the LPS region.
Article in BMC microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Genomic Analysis and Virulence Features of Vibrio cholerae Non-O1/Non-O139 Harbouring CARB-Type β-Lactamases From Freshwater Bodies, Argentina.Environmental microbiology reports · 2025Article
- Structure and Biosynthetic Gene Cluster of Sulfated Capsular Polysaccharide from the Marine BacteriumInternational journal of molecular sciences · 2024Article
- Functional Identification and Genetic Analysis of O-Antigen Gene Clusters of Food-Borne PathogenJournal of microbiology and biotechnology · 2024Article
- Isolation and Characterization of Cholera Toxin Gene-PositiveInfection and drug resistance · 2024Article
- Review
- Stereoselective β-mannosylations and β-rhamnosylations from glycosyl hemiacetals mediated by lithium iodide.Chemical science · 2021Article
- VicPred: AFrontiers in microbiology · 2021Article
- Identification ofFrontiers in microbiology · 2020Article
- Genetic Structure, Function, and Evolution of Capsule Biosynthesis Loci inFrontiers in microbiology · 2020Article
- Comparative Analysis of Extended-Spectrum-β-Lactamase CTX-M-65-Producing Salmonella enterica Serovar Infantis Isolates from Humans, Food Animals, and Retail Chickens in the United States.Antimicrobial agents and chemotherapy · 2017Article
- Uncovering the components of the Francisella tularensis virulence stealth strategy.Frontiers in cellular and infection microbiology · 2014Review
- Structural characterization of the extracellular polysaccharide from Vibrio cholerae O1 El-Tor.PloS one · 2014Article
- Whole-genome sequencing of gentamicin-resistant Campylobacter coli isolated from U.S. retail meats reveals novel plasmid-mediated aminoglycoside resistance genes.Antimicrobial agents and chemotherapy · 2013Article
- Complete genome sequence of the marine fish pathogen Vibrio anguillarum harboring the pJM1 virulence plasmid and genomic comparison with other virulent strains of V. anguillarum and V. ordalii.Infection and immunity · 2011Article
- Genetic diversity of O-antigen biosynthesis regions in Vibrio cholerae.Applied and environmental microbiology · 2011Article
- Occurrence of L-iduronic acid and putative D-glucuronyl C5-epimerases in prokaryotes.Glycoconjugate journal · 2011Article
- Evidence for the horizontal transfer of an unusual capsular polysaccharide biosynthesis locus in marine bacteria.Infection and immunity · 2010Article
- Genetic analysis of the capsule polysaccharide (K antigen) and exopolysaccharide genes in pandemic Vibrio parahaemolyticus O3:K6.BMC microbiology · 2010Article
- Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis.PloS one · 2010Article
- Vibrio vulnificus biotype 2 serovar E gne but not galE is essential for lipopolysaccharide biosynthesis and virulence.Infection and immunity · 2008Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundIn V. cholerae, the biogenesis of capsule polysaccharide is poorly understood. The elucidation of capsule structure and biogenesis is critical to understanding the evolution of surface polysaccharide and the internal relationship between the capsule and LPS in this species. V. cholerae serogroup O31 NRT36S, a human pathogen that produces a heat-stable enterotoxin (NAG-ST), is encapsulated. Here, we report the covalent structure and studies of the biogenesis of the capsule in V. cholerae NRT36S.
resultsThe structure of the capsular (CPS) polysaccharide was determined by high resolution NMR spectroscopy and shown to be a complex structure with four residues in the repeating subunit. The gene cluster of capsule biogenesis was identified by transposon mutagenesis combined with whole genome sequencing data (GenBank accession DQ915177). The capsule gene cluster shared the same genetic locus as that of the O-antigen of lipopolysaccharide (LPS) biogenesis gene cluster. Other than V. cholerae O139, this is the first V. cholerae CPS for which a structure has been fully elucidated and the genetic locus responsible for biosynthesis identified.
conclusionThe co-location of CPS and LPS biosynthesis genes was unexpected, and would provide a mechanism for simultaneous emergence of new O and K antigens in a single strain. This, in turn, may be a key element for V. cholerae to evolve new strains that can escape immunologic detection by host populations.
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