ArticleClinical and experimental immunology2007
Effector T lymphocytes in well-nourished and malnourished infected children.
Article in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pooled it
- Impact of protein supplementation and care and support on body composition and CD4 count among HIV-infected women living in rural India: results from a randomized pilot clinical trial.AIDS and behavior · 2013Trial
- Glucocorticoids intrinsically redirect naïve CD4+ T cells to the bone marrow for preservation in malnourished mice.Biology open · 2026Article
- Review
- Protein undernutrition reduces the efficacy of praziquantel in a murine model of Schistosoma mansoni infection.PLoS neglected tropical diseases · 2022Article
- Mechanisms of Kwashiorkor-Associated Immune Suppression: Insights From Human, Mouse, and Pig Studies.Frontiers in immunology · 2022Review
- Infection in the Developing Brain: The Role of Unique Systemic Immune Vulnerabilities.Frontiers in neurology · 2021Review
- Pathogenic signature of invasive non-typhoidalHuman vaccines & immunotherapeutics · 2020Review
- Anorexia Nervosa and the Immune System-A Narrative Review.Journal of clinical medicine · 2019Review
- Predictive effects of body mass index on immune reconstitution among HIV-infected HAART users in China.BMC infectious diseases · 2019Article
- Impact of Childhood Malnutrition on Host Defense and Infection.Clinical microbiology reviews · 2017Review
- Neurodevelopment: The Impact of Nutrition and Inflammation During Adolescence in Low-Resource Settings.Pediatrics · 2017Review
- Outcomes of human immunodeficiency virus-infected children after anti-retroviral therapy in Malaysia.Journal of paediatrics and child health · 2015Article
- Predictors of Mortality in a Clinic Cohort of HIV-1 Infected Children Initiated on Antiretroviral Therapy in Jos, Nigeria.Journal of AIDS & clinical research · 2014Article
- Prevalence and factors associated with cryptococcal antigenemia among severely immunosuppressed HIV-infected adults in Uganda: a cross-sectional study.Journal of the International AIDS Society · 2012Article
- An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Article
- Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden.Journal of biomedical science · 2011Article
- Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya: a prospective cohort.BMC pediatrics · 2010Article
- Nutritional aspects of HIV-associated wasting in sub-Saharan Africa.The American journal of clinical nutrition · 2010Article
- Macronutrient supplementation for malnourished HIV-infected adults: a review of the evidence in resource-adequate and resource-constrained settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms involved in impaired immunity in malnourished children are not well understood. CD4(+) CD62L(-) and CD8(+) CD28(-) do not express the naive cell markers CD62L and CD28, suggesting that they function as effector T cells. Using a flow cytometry-based analysis we examined the proportions of CD4(+) CD62L(-) and CD8(+) CD28(-) T cell subsets in well-nourished infected (WNI) and malnourished infected (MNI) children. Here we report that WNI children had a higher percentage of CD4(+) CD62L(-) (11.1 +/- 1.0) and CD8(+) D28(-) (40.2 +/- 5.0) T cell subsets than healthy (6.5 +/- 1.0 and 23.9 +/- 4.8) and MNI children (7.4 +/- 1.1 and 23.1 +/- 6.2, respectively) (P < 0.5). Data suggest that WNI children respond efficiently against pathogenic microbes. In contrast, relatively low numbers of circulating of CD4(+) CD62L(-) and CD8(+) CD28(-) T cells in MNI children may represent an ineffective response to infection. Levels of effector T cells in children with gastrointestinal infections versus those suffering from respiratory infections were also significantly different within the WNI group. While WNI children with gastrointestinal infections had higher absolute and relative values of CD8(+), and CD8(+) CD28(-) T subsets, by those with respiratory infections had higher values of CD4(+) lymphocytes. However, due to the small number of subjects examined, our results in WNI children should be interpreted with caution and confirmed using a larger sample size. Our data suggest that altered expression of CD62L and CD28 receptors may contribute to impaired T cell function observed in MNI children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.