ArticleLasers in medical science2008
Toluidine blue-mediated photoinactivation of periodontal pathogens from supragingival plaques.
Article in Lasers in medical science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Photodynamic therapy in the treatment of chronic periodontitis: a systematic review and meta-analysis.Lasers in medical science · 2013Pooled it
- In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy onTranslational vision science & technology · 2019Article
- Assessment of Photodynamic Inactivation against Periodontal Bacteria Mediated by a Chitosan Hydrogel in a 3D Gingival Model.International journal of molecular sciences · 2016Article
- Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats.BioMed research international · 2016Article
- Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (vis+wIRA) and Chlorine e6 (Ce6) Eradicates Planktonic Periodontal Pathogens and Subgingival Biofilms.Frontiers in microbiology · 2016Article
- Adjunctive Application of Antimicrobial Photodynamic Therapy in Nonsurgical Periodontal Treatment: A Review of Literature.International journal of molecular sciences · 2015Review
- The effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans attached to surface-modified titanium.Journal of periodontal & implant science · 2015Article
- Article
- Inactivation of Aggregatibacter actinomycetemcomitans by two different modalities of photodynamic therapy using Toluidine blue O or Radachlorin as photosensitizers: an in vitro study.Lasers in medical science · 2015Article
- Effect of Nonsurgical Periodontal Treatment Combined With Diode Laser or Photodynamic Therapy on Chronic Periodontitis: A Randomized Controlled Split-Mouth Clinical Trial.Journal of lasers in medical sciences · 2015Article
- Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond.Current opinion in pharmacology · 2013Review
- Photodynamic therapy in dentistry: a literature review.Clinical oral investigations · 2013Review
- In vitro toxicity of photodynamic antimicrobial chemotherapy on human keratinocytes proliferation.Lasers in medical science · 2013Article
- Review
- Histomorphometric and microbiological assessment of photodynamic therapy as an adjuvant treatment for periodontitis: a short-term evaluation of inflammatory periodontal conditions and bacterial reduction in a rat model.Photomedicine and laser surgery · 2011Article
- Susceptibility of Candida albicans, Staphylococcus aureus, and Streptococcus mutans biofilms to photodynamic inactivation: an in vitro study.Lasers in medical science · 2011Article
- Laser phototherapy in the treatment of periodontal disease. A review.Lasers in medical science · 2010Review
- Toluidine blue-mediated photodynamic therapy of oral wound infections in rats.Lasers in medical science · 2010Article
- The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms.Journal of periodontal research · 2009Article
- Histological evaluation of the safety of toluidine blue-mediated photosensitization to periodontal tissues in mice.Lasers in medical science · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to assess the effect of toluidine blue (TB)-mediated photodynamic inactivation of periodontal pathogens (PP) from periodontopathic patients. Photodynamic therapy (PDT) was carried out using TB and 635 nm laser light irradiation. The bactericidal effect was evaluated, and important PDT parameters including light intensity, energy dose, and TB concentration were determined. Our findings suggest that TB-mediated lethal photosensitization of PP in vivo is possible. However, to obtain ideal bactericidal effect, higher doses of light and photosensitizer should be required in treatment in vivo than their planktonic counterparts. The best therapeutic effect was observed in treatment by 1 mg/ml TB combined with 12 J/cm(2) at 159 mW/cm(2) light irradiation. Moreover, because of the considerable interindividual differences of bacterial populations, TB-mediated PDT might not be equally effective among periodontopathic patients, and further studies on improvement of this therapeutic modality is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.