ArticleIntensive care medicine2007
Ability of family members to predict patient's consent to critical care research.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01232621 (A Randomized Pilot Study of Different Methods of Approaching Substitute Decision Makers Regarding Research Participation in the Intensive Care Unit), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Pilot Study of Different Methods of Approaching Substitute Decision Makers Regarding Research Participation in the Intensive Care Unit: The Approach Study
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Views on consent approaches used in emergency and critical care research: a rapid, systematic review.Trials · 2026Pooled it
- Trial
- Artificial intelligence and medical futility.BMC medical informatics and decision making · 2026Review
- Proxy consent to clinical research participation: how should it be justified?Medicine, health care, and philosophy · 2026Article
- The Enduring Promise of Personalising Patient Preference Prediction.Neuroethics · 2026Review
- Article
- Respecting formerly autonomous persons: clarifying the role of the Personalised Patient Preference Predictor (P4) in substituted judgement.Journal of medical ethics · 2025Article
- "I Wish I Knew": Assessing Older Adults' Perceived and Actual Knowledge of Their Partners' End-of-Life Preferences.Innovation in aging · 2025Article
- A Personalized Patient Preference Predictor for Substituted Judgments in Healthcare: Technically Feasible and Ethically Desirable.The American journal of bioethics : AJOB · 2024Article
- Public perception of participation in low-risk clinical trials in critical care using waived consent: a Canadian national survey.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Impact of advance directives on the variability between intensivists in the decisions to forgo life-sustaining treatment.Critical care (London, England) · 2020Article
- Advances and challenges in conducting ethical trials involving populations lacking capacity to consent: A decade in review.Contemporary clinical trials · 2020Article
- Intensive care unit patients' opinion on enrollment in clinical research: A multicenter survey.PloS one · 2020Observational
- Advance directives as a tool to respect patients' values and preferences: discussion on the case of Alzheimer's disease.BMC medical ethics · 2018Article
- Ethical challenges involved in obtaining consent for research from patients hospitalized in the intensive care unit.Annals of translational medicine · 2017Article
- An Alternative Consent Process for Minimal Risk Research in the ICU.Critical care medicine · 2017Article
- Surrogate consent to non-beneficial research: erring on the right side when substituted judgments may be inaccurate.Theoretical medicine and bioethics · 2016Article
- Perspectives of Decisional Surrogates and Patients Regarding Critical Illness Genetic Research.AJOB empirical bioethics · 2016Article
- Medical research in emergency research in the European Union member states: tensions between theory and practice.Intensive care medicine · 2014Review
- ICU research: the impact of invasiveness on informed consent.Intensive care medicine · 2013Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA European Union Directive provides for the designation of a surrogate who can consent to or refuse inclusion of an incapacitated patient in research studies. The accuracy with which surrogates consent to research on behalf of patients has not been evaluated in the intensive care unit (ICU).
methodsA prospective multicenter study was conducted in ten ICUs of the French Famirea study group between July and October 2004. Two hypothetical studies were simultaneously submitted to the patient, surrogate, and physician at the time that the patient was discharged to a ward. One study involved minimal risk and the other greater-than-minimal risk to the patients.
resultsWith the minimal risk study there was patient-surrogate discrepancy in 32% of cases and patient-physician discrepancy in 25%. Corresponding figures with the greater-than-minimal risk study were 42% and 46%. None of the collected variables differed significantly between cases with and without patient-surrogate discrepancy.
conclusionsFamily members designated to serve as surrogate decision makers may fail to accurately consent to research for critically ill patients in one-third to nearly one-half of cases.
Indexed as
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17361388What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.