ArticleThe British journal of ophthalmology2007
Immunolocalisation of E-cadherin and beta-catenin in human pterygium.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Z-shaped incision without epithelial resection in pterygium surgery.International journal of ophthalmology · 2024Article
- A case of spontaneous avulsion of primary pterygium analyzed with anterior segment optical coherence tomography.American journal of ophthalmology case reports · 2022Article
- Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin).Eye (London, England) · 2019Article
- Expression of prostaglandin EInternational ophthalmology · 2018Article
- Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis.International journal of ophthalmology · 2017Review
- miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.Experimental eye research · 2013Article
- Immunohistochemical detection of Hsp90 and Ki-67 in pterygium.Diagnostic pathology · 2013Article
- Expression of vascular endothelial growth factor C in human pterygium.Histochemistry and cell biology · 2013Article
- Lymphatic microvessel density as a predictive marker for the recurrence time of pterygium: a three-year follow-up study.Molecular vision · 2013Article
- Comparative evaluation of lymphatic vessels in primary versus recurrent pterygium.Eye (London, England) · 2012Article
- Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium.International journal of ophthalmology · 2012Article
- Relations between lymphangiogenesis and the size of pterygium.International journal of ophthalmology · 2012Article
- Tissue factor expression in human pterygium.Molecular vision · 2011Article
- CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization.Molecular vision · 2010Article
- Proliferative and migratory aptitude in pterygium.Histochemistry and cell biology · 2010Article
- E-cadherin promoter hypermethylation may contribute to protein inactivation in pterygia.Molecular vision · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe pterygium represents an invasion of a wing of altered ocular surface tissue into the normal cornea. The head itself is slightly elevated and white, which is the only site of firm adhesion to the globe. The mechanisms of cell proliferation and adhesion in pterygium epithelium, however, are unknown. The aim of this study was to analyse the expression of cell adhesion molecules in pterygium tissues.
methodsSix pterygia were surgically removed using the bare-sclera procedure, and two normal corneas and a normal bulbar conjunctiva were also obtained. Formalin-fixed, paraffin-embedded tissues were analysed by immunohistochemistry with anti-E-cadherin and beta-catenin antibodies.
resultsImmunoreactivity for E-cadherin was not detected in the normal cornea and conjunctiva. In contrast, all corneal and conjunctival epithelial cells showed a weak homogeneous immunoreaction for beta-catenin on the cell membrane. In the pterygium head, the thickness was relatively marked compared with the body, and normal conjunctival and corneal epithelia. E-cadherin as well as beta-catenin was heterogeneously expressed in the cell membrane and cytoplasm of a variety of epithelial cells, whereas the expression was less marked in the body. Several epithelial cells showed intense nuclear immunoreactivity for beta-catenin. Immunoreactivity of beta-catenin, but not E-cadherin, was detected in only a few stromal cells, which were less marked than in epithelial cells.
conclusionIt is suggested that E-cadherin and beta-catenin are concentrated in pterygium tissue, and are possibly involved with epithelial proliferation and adhesion.
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