ArticleProceedings of the National Academy of Sciences of the United States of America2007
Small RNA-mediated chromatin silencing directed to the 3' region of the Arabidopsis gene encoding the developmental regulator, FLC.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 129 citations in OpenAlex.
- Presence and function of small RNAs during plant reproduction.RNA biology · 2026Review
- Antisense transcription from stress-responsive transcription factors fine-tunes the cold response in Arabidopsis.The Plant cell · 2024Article
- Coding and noncoding transcriptomes of NODULIN HOMEOBOX (NDX)-deficient Arabidopsis inflorescence.Scientific data · 2023Article
- Mapping of Two Major QTLs Controlling Flowering Time inPlants (Basel, Switzerland) · 2022Article
- NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis.Nature communications · 2022Article
- Antagonistic cotranscriptional regulation through ARGONAUTE1 and the THO/TREX complex orchestratesProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The ferroxidase LPR5 functions in the maintenance of phosphate homeostasis and is required for normal growth and development of rice.Journal of experimental botany · 2020Article
- Tissue-specific transposon-associated small RNAs in the gymnosperm tree, Norway spruce.BMC genomics · 2019Article
- PRC2 recruitment and H3K27me3 deposition atScience advances · 2019Article
- RNA Splicing ofFrontiers in plant science · 2019Review
- Plant small RNAs: the essential epigenetic regulators of gene expression for salt-stress responses and tolerance.Plant cell reports · 2018Review
- Translational repression by a miniature inverted-repeat transposable element in the 3' untranslated region.Nature communications · 2017Article
- Control of seed dormancy in Arabidopsis by a cis-acting noncoding antisense transcript.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Emerging Trends in Epigenetic Regulation of Nutrient Deficiency Response in Plants.Molecular biotechnology · 2016Article
- Tuning growth cycles of Brassica crops via natural antisense transcripts of BrFLC.Plant biotechnology journal · 2016Article
- Flowering Locus C's Lessons: Conserved Chromatin Switches Underpinning Developmental Timing and Adaptation.Plant physiology · 2015Review
- Environmental perception and epigenetic memory: mechanistic insight through FLC.The Plant journal : for cell and molecular biology · 2015Review
- Article
- Mutual interdependence of splicing and transcription elongation.Transcription · 2015Review
- Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state.Nature · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small RNA-mediated chromatin silencing is well characterized for repeated sequences and transposons, but its role in regulating single-copy endogenous genes is unclear. We have identified two small RNAs (30 and 24 nucleotides) corresponding to the reverse strand 3' to the canonical poly(A) site of FLOWERING LOCUS C (FLC), an Arabidopsis gene encoding a repressor of flowering. Genome searches suggest that these RNAs originate from the FLC locus in a genomic region lacking repeats. The 24-nt small RNA, which is most abundant in developing fruits, is absent in mutants defective in RNA polymerase IVa, RNA-DEPENDENT RNA POLYMERASE 2, and DICER-LIKE 3, components required for RNAi-mediated chromatin silencing. The corresponding genomic region shows histone 3 lysine 9 dimethylation, which was reduced in a dcl2,3,4 triple mutant. Investigations into the origins of the small RNAs revealed a polymerase IVa-dependent spliced, antisense transcript covering the 3' FLC region. Mutation of this genomic region by T-DNA insertion led to FLC misexpression and delayed flowering, suggesting that RNAi-mediated chromatin modification is an important component of endogenous pathways that function to suppress FLC expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.