ArticleProceedings of the National Academy of Sciences of the United States of America2007
Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 136 citations in OpenAlex.
- Architecture, permeability, disruption dynamics and remodeling of tight junction proteins: Implications for performance, health, and welfare of the broiler chicken.Poultry science · 2026Review
- Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats.Heliyon · 2024Article
- Gemigliptin Improves Salivary Gland Dysfunction in D-Galactose-Injected Aging Rats.Pharmaceutics · 2023Article
- Submandibular gland epithelial development and the importance of junctions.Tissue barriers · 2023Review
- Review
- Ontogenetic development of the water channel protein AQP5 in mouse salivary gland tissue.Cell and tissue research · 2023Article
- Article
- Aquaporin-5 Dynamic Regulation.International journal of molecular sciences · 2023Review
- Extending applications of AFM to fluidic AFM in single living cell studies.Journal of cellular physiology · 2022Review
- Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress.Cells · 2022Article
- Aquaporin-5 in breast cancer.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Review
- Exosomally Targeting microRNA23a Ameliorates Microvascular Endothelial Barrier Dysfunction Following Rickettsial Infection.Frontiers in immunology · 2022Article
- A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review).Biomedical reports · 2021Review
- Dietary fatty acids and the time elapsed from their intake are related to their composition in rat submandibular gland and salivary flow rates.Clinical oral investigations · 2020Article
- Influence of Different Feed Physical Forms on Mandibular Gland in Growing Pigs.Animals : an open access journal from MDPI · 2020Article
- Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands.Heliyon · 2019Article
- [Role and mechanism of muscarinic acetylcholine receptor in the regulation of submandibular gland secretion].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Fasudil alleviates LPS-induced lung injury by restoring aquaporin 5 expression and inhibiting inflammation in lungs.Journal of biomedical research · 2019Article
- A microfluidic model of human brain (μHuB) for assessment of blood brain barrier.Bioengineering & translational medicine · 2019Article
- N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.The Journal of cell biology · 2019Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
To investigate potential physiological interactions between the transcellular and paracellular pathways of water transport, we asked whether targeted deletion of Aquaporin 5 (AQP5), the major transcellular water transporter in salivary acinar cells, affected paracellular transport of 4-kDa FITC-labeled dextran (FITC-D), which is transported through the paracellular but not the transcellular route. After i.v. injection of FITC-D into either AQP5 wild-type or AQP5-/- mice and saliva collection for fixed time intervals, we show that the relative amount of FITC-D transported in the saliva of AQP5-/- mice is half that in matched AQP5+/+ mice, indicating a 2-fold decrease in permeability of the paracellular barrier in mice lacking AQP5. We also found a significant difference in the proportion of transcellular vs. paracellular transport between male and female mice. Freeze-fracture electron microscopy revealed an increase in the number of tight junction strands of both AQP5+/+ and AQP5-/- male mice after pilocarpine stimulation but no change in strand number in female mice. Average acinar cell volume was increased by approximately 1.4-fold in glands from AQP5-/- mice, suggesting an alteration in the volume-sensing machinery of the cell. Western blots revealed that expression of Claudin-7, Claudin-3, and Occludin, critical proteins that regulate the permeability of the tight junction barrier, were significantly decreased in AQP5-/- compared with AQP5+/+ salivary glands. These findings reveal the existence of a gender-influenced molecular mechanism involving AQP5 that allows transcellular and paracellular routes of water transport to act in conjunction.
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