ArticleProceedings of the National Academy of Sciences of the United States of America2007
Developmental hearing loss eliminates long-term potentiation in the auditory cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Article
- Cognitive decline in acoustic neuroma patients: An investigation based on resting-state functional magnetic resonance imaging and voxel-based morphometry.Frontiers in psychiatry · 2022Article
- Effects of Multisession Anodal Electrical Stimulation of the Auditory Cortex on Temporary Noise-Induced Hearing Loss in the Rat.Frontiers in neuroscience · 2021Article
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Article
- Cisplatin induces calcium ion accumulation and hearing loss by causing functional alterations in calcium channels and exocytosis.American journal of translational research · 2019Article
- Developmental hearing loss impedes auditory task learning and performance in gerbils.Hearing research · 2017Article
- Developmental exposure to PCBs alters the activation of the auditory cortex in response to GABANeurotoxicology · 2016Article
- Alterations in gray matter volume due to unilateral hearing loss.Scientific reports · 2016Article
- Central plasticity and dysfunction elicited by aural deprivation in the critical period.Frontiers in neural circuits · 2015Review
- Failed stabilization for long-term potentiation in the auditory cortex of FMR1 knockout mice.PloS one · 2014Article
- Central gain control in tinnitus and hyperacusis.Frontiers in neurology · 2014Review
- Functional and structural changes throughout the auditory system following congenital and early-onset deafness: implications for hearing restoration.Frontiers in systems neuroscience · 2013Review
- Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Developmental neuroplasticity after cochlear implantation.Trends in neurosciences · 2012Review
- Loss of prestin does not alter the development of auditory cortical dendritic spines.Neural plasticity · 2011Article
- Article
- Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Normal hearing is required for the emergence of long-lasting inhibitory potentiation in cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Severe hearing loss during early development is associated with deficits in speech and language acquisition. Although functional studies have shown a deafness-induced alteration of synaptic strength, it is not known whether long-term synaptic plasticity depends on auditory experience. In this study, sensorineural hearing loss (SNHL) was induced surgically in developing gerbils at postnatal day 10, and excitatory synaptic plasticity was examined subsequently in a brain slice preparation that preserves the thalamorecipient auditory cortex. Extracellular stimuli were applied at layer 6 (L6), whereas evoked excitatory synaptic potentials (EPSPs) were recorded from L5 neurons by using a whole-cell current clamp configuration. In control neurons, the conditioning stimulation of L6 significantly altered EPSP amplitude for at least 1 h. Approximately half of neurons displayed long-term potentiation (LTP), whereas the other half displayed long-term depression (LTD). In contrast, SNHL neurons displayed only LTD after the conditioning stimulation of L6. Finally, the vast majority of neurons recorded from control prehearing animals (postnatal days 9-11) displayed LTD after L6 stimulation. Thus, normal auditory experience may be essential for the maturation of synaptic plasticity mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.