ArticleProceedings of the National Academy of Sciences of the United States of America2007
Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 181 citations in OpenAlex.
- Distinct medial amygdala oxytocin receptor neurons projections respectively control consolation or aggression in male mandarin voles.Nature communications · 2024Article
- Sex Differences in Social Cognition.Current topics in behavioral neurosciences · 2023Review
- Characterization of anFrontiers in pharmacology · 2023Article
- Dynamic influences on the neural encoding of social valence.Nature reviews. Neuroscience · 2022Review
- The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Neural systems that facilitate the representation of social rank.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Acute social isolation and regrouping cause short- and long-term molecular changes in the rat medial amygdala.Molecular psychiatry · 2022Article
- Social factors and the neurobiology of pathogen avoidance.Biology letters · 2022Review
- The modulation of emotional and social behaviors by oxytocin signaling in limbic network.Frontiers in molecular neuroscience · 2022Review
- Sex-Specific Social Behavior and Amygdala Proteomic Deficits inFrontiers in behavioral neuroscience · 2021Article
- Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models.Current research in neurobiology · 2021Review
- Pathogens, odors, and disgust in rodents.Neuroscience and biobehavioral reviews · 2020Review
- Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior.Hormones and behavior · 2019Review
- Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling.Frontiers in neuroendocrinology · 2019Review
- Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators.Frontiers in behavioral neuroscience · 2019Review
- Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior.Psychology research and behavior management · 2019Review
- Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery.Frontiers in neuroendocrinology · 2018Review
- The role of social cognition in parasite and pathogen avoidance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Parent-offspring cohabitation after weaning inhibits partner preference and alters central oxytocin and dopamine systems in adult mandarin vole.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Rapid actions of oestrogens and their receptors on memory acquisition and consolidation in females.Journal of neuroendocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social recognition constitutes the basis of social life. In male mice and rats, social recognition is known to be governed by the neuropeptide oxytocin (OT) through its action on OT receptors (OTRs) in the medial amygdala. In female rats and mice, which have sociosexual behaviors controlling substantial investment in reproduction, an important role for OT in sociosexual behaviors has also been shown. However, the site in the female brain for OT action on social recognition is still unknown. Here we used a customized, controlled release system of biodegradable polymeric microparticles to deliver, in the medial amygdala of female mice, "locked nucleic acid" antisense (AS) oligonucleotides with sequences specific for the mRNA of the OTR gene. We found that single bilateral intraamygdala injections of OTR AS locked nucleic acid oligonucleotides several days before behavioral testing reduced social recognition. Thus, we showed that gene expression for OTR specifically in the amygdala is required for normal social recognition in female mice. Importantly, during the same experiment, we performed a detailed ethological analysis of mouse behavior revealing that OTR AS-treated mice underwent an initial increase in ambivalent risk-assessment behavior. Other behaviors were not affected, thus revealing specific roles for amygdala OTR in female social recognition potentially mediated by anxiety in a social context. Understanding the functional genomics of OT and OTR in social recognition should help elucidate the neurobiological bases of human disorders of social behavior (e.g., autism).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.