ArticleProceedings of the National Academy of Sciences of the United States of America2007
A statistical phylogeography of influenza A H5N1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82 citing papers in PubMed, 174 citations in OpenAlex.
- Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Trial
- Marked Antigenic Divergence and Evolutionary Analysis of H5 AIVs from Wild Birds in East China, 2013-2022.Animals : an open access journal from MDPI · 2026Article
- Molecular and antigenic characteristics of the influenza B virus in Guangzhou, 2022-2023.Virology journal · 2026Article
- Quantifying Time-Dependent Predictors for the International Spatial Spread of Highly Pathogenic Avian Influenza H5NX: Focus on Trade and Surveillance Efforts.Transboundary and emerging diseases · 2025Article
- Phylogenetic analysis of migration, differentiation, and class switching in B cells.PLoS computational biology · 2022Article
- The impact of sampling bias on viral phylogeographic reconstruction.PLOS global public health · 2022Article
- Phylogeographic reconstruction using air transportation data and its application to the 2009 H1N1 influenza A pandemic.PLoS computational biology · 2020Article
- A Fast Likelihood Method to Reconstruct and Visualize Ancestral Scenarios.Molecular biology and evolution · 2019Article
- Incorporating sampling uncertainty in the geospatial assignment of taxa for virus phylogeography.Virus evolution · 2019Article
- A Fréchet tree distance measure to compare phylogeographic spread paths across trees.Scientific reports · 2018Article
- Identifying key bird species and geographical hotspots of avian influenza A (H7N9) virus in China.Infectious diseases of poverty · 2018Article
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- Genomic diversity and phylogeography of norovirus in China.BMC medical genomics · 2017Article
- Avian influenza overview October 2016-August 2017.EFSA journal. European Food Safety Authority · 2017Article
- The impact of migratory flyways on the spread of avian influenza virus in North America.BMC evolutionary biology · 2017Article
- Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses.Scientific reports · 2017Article
- Genetic Characteristic and Global Transmission of Influenza A H9N2 Virus.Frontiers in microbiology · 2017Article
- The global spread of HIV-1 subtype B epidemic.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus.Virologica Sinica · 2016Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The geographic diffusion of highly pathogenic influenza A H5N1 has largely been traced from the perspective of the virus's victims. Birds of a variety of avian orders have been sampled across localities, and their infection has been identified by a general genetic test. Another approach tracks the migration from the perspective of the virus alone, by way of a phylogeography of H5N1 genetic sequences. Although several phylogenies in the literature have labeled H5N1 clades by geographic region, none has analytically inferred the history of the virus's migration. With a statistical phylogeography of 192 hemagglutinin and neuraminidase isolates, we show that the Chinese province of Guangdong is the source of multiple H5N1 strains spreading at both regional and international scales. In contrast, Indochina appears to be a regional sink, at the same time demonstrating bidirectional dispersal among localities within the region. An evolutionary trace of HA(1) across the phylogeography suggests a mechanism by which H5N1 is able to infect repeated cycles of host species across localities, regardless of the host species first infected in each locale. The trace also hypothesizes amino acid replacements that preceded the first recorded outbreak of pathogenic H5N1 in Hong Kong, 1997.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.