ArticleProceedings of the National Academy of Sciences of the United States of America2007
Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome.Life science alliance · 2024Article
- Plasticity of bone marrow-derived cell differentiation depending on microenvironments in the skin.Frontiers in physiology · 2024Article
- Expression of proinflammatory cytokines and proinsulin by bone marrow-derived cells for fracture healing in long-term diabetic mice.BMC musculoskeletal disorders · 2023Article
- Complete remission of diabetes with a transient HDAC inhibitor and insulin in streptozotocin mice.Communications biology · 2023Article
- Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion.Communications biology · 2021Article
- A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury.Scientific reports · 2021Article
- Breast tumor cell hybrids form spontaneouslyAPL bioengineering · 2018Article
- Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Bone marrow-derived TNF-α causes diabetic neuropathy in mice.Diabetologia · 2015Article
- Emerging roles of hematopoietic cells in the pathobiology of diabetic complications.Trends in endocrinology and metabolism: TEM · 2014Review
- Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy.FEBS letters · 2014Article
- Diabetes impairs the interactions between long-term hematopoietic stem cells and osteopontin-positive cells in the endosteal niche of mouse bone marrow.American journal of physiology. Cell physiology · 2013Article
- Identification and characterization of novel Kirrel isoform during myogenesis.Physiological reports · 2013Article
- It is all in the blood: the multifaceted contribution of circulating progenitor cells in diabetic complications.Experimental diabetes research · 2012Review
- Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Pathogenesis of diabetic neuropathy: bad to the bone.Annals of the New York Academy of Sciences · 2011Review
- Homing of the bone marrow-derived interstitial cells of Cajal is decreased in diabetic mouse intestine.Journal of gastroenterology and hepatology · 2011Article
- Article
- Ginseng on hyperglycemia: effects and mechanisms.Evidence-based complementary and alternative medicine : eCAM · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
We previously reported that diabetes in mice is associated with the appearance of proinsulin-producing (Proins-P) cells in the liver. It was unclear, however, whether these Proins-P bone marrow-derived cells (BMDC) merely transit through the liver or undergo fusion with hepatocytes, normally an extremely rare event. In this study, we found that, in diabetes, BMDC in the liver produce not only Proins but also TNF-alpha, suggesting that diabetes reprograms gene expression in BMDC, turning on "inappropriate" genes. Bone marrow transplantation using genetically marked donor and recipient mice showed that fusion occurs between Proins-P BMDC and hepatocytes. Cell fusion is further supported by the presence of the Y chromosome in Proins-P cells in female mice that received male bone marrow transplantation cells. Morphologically, Proins-P fusion cells are albumin-producing hepatocytes that constitute approximately 2.5% of the liver section area 5 months after diabetes induction. An extensive search failed to reveal any fusion cells in nondiabetic mice. Thus, diabetes causes fusion between Proins-P BMDC and hepatocytes in vivo, an observation that has implications for the pathophysiology of diabetes as well as the fundamental biology of heterotypic cell fusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.