ArticleProceedings of the National Academy of Sciences of the United States of America2007
Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 81 citations in OpenAlex.
- Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends.eLife · 2026Article
- Light-controlled Spo11-less meiotic DNA breaks by MagTAQing lead to chromosomal aberrations.Nucleic acids research · 2025Article
- Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis.Current genetics · 2021Review
- Genome Duplication Increases Meiotic Recombination Frequency: A Saccharomyces cerevisiae Model.Molecular biology and evolution · 2021Article
- SUMO is a pervasive regulator of meiosis.eLife · 2021Article
- Meiotic DNA Repair in the Nucleolus Employs a Nonhomologous End-Joining Mechanism.The Plant cell · 2019Article
- Distributing meiotic crossovers for optimal fertility and evolution.DNA repair · 2019Review
- Heterogeneous transposable elements as silencers, enhancers and targets of meiotic recombination.Chromosoma · 2019Review
- Hotspots for Initiation of Meiotic Recombination.Frontiers in genetics · 2018Review
- Article
- Meiotic Chromosome Association 1 Interacts with TOP3α and Regulates Meiotic Recombination in Rice.The Plant cell · 2017Article
- Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.Molecular and cellular biology · 2017Article
- Impact of histone H4K16 acetylation on the meiotic recombination checkpoint inMicrobial cell (Graz, Austria) · 2016Article
- Fine-Scale Crossover Rate Variation on the Caenorhabditis elegans X Chromosome.G3 (Bethesda, Md.) · 2016Article
- Insights into epigenetic landscape of recombination-free regions.Chromosoma · 2016Review
- Initiation of meiotic homologous recombination: flexibility, impact of histone modifications, and chromatin remodeling.Cold Spring Harbor perspectives in biology · 2015Review
- Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage.Epigenetics & chromatin · 2015Article
- Article
- OsHUS1 facilitates accurate meiotic recombination in rice.PLoS genetics · 2014Article
- New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination.Nucleic acids research · 2012Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In eukaryotes, meiotic recombination events are distributed nonrandomly in the genome, with certain regions having high levels of recombination (hotspots) and others having low levels (coldspots). Species with similar DNA sequences (for example, chimpanzees and humans) can have strikingly different patterns of hotspots and coldspots. Below, by using a microarray analysis that allows us to measure the frequency of the meiosis-specific double-strand DNA breaks (DSBs) of all 6,000 yeast genes, we show that mutation of a single gene (SIR2), which encodes a histone deacetylase, significantly changes DSB frequencies of 12% of yeast genes, elevating DSBs of 5%, and reducing DSBs of 7%. Many of the genes with repressed recombination are located in large (50-100 kb) regions located near, but not at, the telomeres. Some of the genes with altered frequencies of DSBs (including the ribosomal RNA gene cluster) are known targets of Sir2p deacetylation in the wild-type strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.