ArticleProceedings of the National Academy of Sciences of the United States of America2007
Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- NK2.2/Vnd acts as a transcriptional activator of deadpan to maintain neuroblast identity in Drosophila embryos.Genes & genomics · 2026Article
- Genome-Wide Expression Analysis of Long Noncoding RNAs and Their Target Genes in MetafemaleInternational journal of molecular sciences · 2023Article
- Article
- Review
- Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors.Development (Cambridge, England) · 2018Article
- Article
- Gene expression profiles uncover individual identities of gnathal neuroblasts and serial homologies in the embryonic CNS of Drosophila.Development (Cambridge, England) · 2016Article
- The role of Dichaete in transcriptional regulation during Drosophila embryonic development.BMC genomics · 2013Article
- The sox gene Dichaete is expressed in local interneurons and functions in development of the Drosophila adult olfactory circuit.Developmental neurobiology · 2013Article
- Identifying targets of the Sox domain protein Dichaete in the Drosophila CNS via targeted expression of dominant negative proteins.BMC developmental biology · 2013Article
- Ind represses msh expression in the intermediate column of the Drosophila neuroectoderm, through direct interaction with upstream regulatory DNA.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Identification of Ind transcription activation and repression domains required for dorsoventral patterning of the CNS.Mechanisms of development · 2009Article
- The Drosophila homeodomain transcription factor, Vnd, associates with a variety of co-factors, is extensively phosphorylated and forms multiple complexes in embryos.The FEBS journal · 2008Article
- Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer.Mechanisms of developmentArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Mechanisms regulating CNS pattern formation and neural precursor formation are remarkably conserved between Drosophila and vertebrates. However, to date, few direct connections have been made between genes that pattern the early CNS and those that trigger neural precursor formation. Here, we use Drosophila to link directly the function of two evolutionarily conserved regulators of CNS pattern along the dorsoventral axis, the homeodomain protein Ind and the Sox-domain protein Dichaete, to the spatial regulation of the proneural gene achaete (ac) in the embryonic CNS. We identify a minimal achaete regulatory region that recapitulates half of the wild-type ac expression pattern in the CNS and find multiple putative Dichaete-, Ind-, and Vnd-binding sites within this region. Consensus Dichaete sites are often found adjacent to those for Vnd and Ind, suggesting that Dichaete associates with Ind or Vnd on target promoters. Consistent with this finding, we observe that Dichaete can physically interact with Ind and Vnd. Finally, we demonstrate the in vivo requirement of adjacent Dichaete and Ind sites in the repression of ac gene expression in the CNS. Our data identify a direct link between the molecules that pattern the CNS and those that specify distinct cell-types.
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