ArticleProceedings of the National Academy of Sciences of the United States of America2007
Heterotrimeric G protein signaling in the Arabidopsis unfolded protein response.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features.Frontiers in plant science · 2022Pooled it
- Arabidopsis Heterotrimeric G Beta Variants Shape Plant Development and Modulate Responses to Endoplasmic Reticulum Stress and Salt Stress.Plant, cell & environment · 2026Article
- Extra-large G proteins and their roles in plant development and responses to environmental stresses.Frontiers in plant science · 2026Review
- Transcriptomic analysis of reduced thermotolerance inFrontiers in plant science · 2026Article
- Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity.Molecular plant · 2025Article
- Trade-Off Regulation in Plant Growth and Stress Responses Through the Role of Heterotrimeric G Protein Signaling.Plants (Basel, Switzerland) · 2024Review
- Arabidopsis AGB1 participates in salinity response through bZIP17-mediated unfolded protein response.BMC plant biology · 2024Article
- G-Protein β-Subunit GeneInternational journal of molecular sciences · 2023Article
- The interplay of GTP-binding protein AGB1 with ER stress sensors IRE1a and IRE1b modulates Arabidopsis unfolded protein response and bacterial immunity.Plant signaling & behavior · 2022Article
- The Rice Malectin Regulates Plant Cell Death and Disease Resistance by Participating in Glycoprotein Quality Control.International journal of molecular sciences · 2022Article
- Review
- Unfolded protein response in balancing plant growth and stress tolerance.Frontiers in plant science · 2022Review
- cAMP-Independent Activation of the Unfolded Protein Response by Cholera Toxin.Infection and immunity · 2021Article
- LUNAPARK Is an E3 Ligase That Mediates Degradation of ROOT HAIR DEFECTIVE3 to Maintain a Tubular ER Network in Arabidopsis.The Plant cell · 2020Article
- The loss of SMG1 causes defects in quality control pathways in Physcomitrella patens.Nucleic acids research · 2018Article
- Genetic and Systematic Approaches Toward G Protein-Coupled Abiotic Stress Signaling in Plants.Frontiers in plant science · 2018Review
- Endoplasmic Reticulum Stress Response in Arabidopsis Roots.Frontiers in plant science · 2017Article
- Functional and regulatory conservation of the soybean ER stress-induced DCD/NRP-mediated cell death signaling in plants.BMC plant biology · 2016Article
- A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins.Nature communications · 2016Article
- Endoplasmic Reticulum Stress Signaling in Plant Immunity--At the Crossroad of Life and Death.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present evidence that heterotrimeric G protein signaling is involved in cell death associated with the unfolded protein response (UPR) in Arabidopsis. Seedlings of homozygous agb1-2 (Gbeta-null mutation) mutant plants are markedly more resistant to growth inhibition by the protein glycosylation inhibitor tunicamycin (Tm) than either wild-type plants or gpa1-4 (Galpha-null mutation) mutants. Leaves of older Gbeta mutant plants show much less cell death when infiltrated with Tm than leaves of wild-type plants. The transcriptional response of Gbeta mutant plants to Tm is less pronounced than that of wild-type plants, as is the accumulation of BiP chaperone proteins. A majority of the Arabidopsis Gbeta protein is associated with the endoplasmic reticulum (ER) and cofractionates with membrane-associated ER luminal BiP. Consistent with its ER localization, Gbeta protein is degraded during the UPR, whereas Galpha protein is not. Taken together, these observations imply that the Gbeta protein, which forms a stable heterodimer with the Ggamma subunit, is involved in the signaling events that trigger UPR-associated cell death. The different Tm sensitivities of Galpha and Gbeta mutants, the ER localization of Gbeta, and the differential stabilities of Galpha and Gbeta proteins during the UPR suggest that the Gbetagamma complex serves a signaling function in the ER independent of its function in the Galphabetagamma heterotrimer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.