ArticleProceedings of the National Academy of Sciences of the United States of America2007
Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection.PLoS pathogens · 2012Trial
- Polymorphisms Influence the Expression of the Fas and FasL Genes in COVID-19.International journal of molecular sciences · 2025Article
- Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon.Developmental cell · 2024Article
- Targeting Epithelium Dysfunction and Impaired Nasal Biofilms to Treat Immunological, Functional, and Structural Abnormalities of Chronic Rhinosinusitis.International journal of molecular sciences · 2023Review
- Article
- Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps.The Journal of allergy and clinical immunology · 2021Article
- A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor Is Highly Susceptible to Oral Infection with Clinical Isolates of Enterovirus 71.Journal of virology · 2019Article
- Direct Antiviral Mechanisms of Interferon-Gamma.Immune network · 2018Review
- Overview of the IL-1 family in innate inflammation and acquired immunity.Immunological reviews · 2018Review
- A functional variant at miRNA-122 binding site in IL-1a 3' UTR predicts risk of recurrence in patients with oropharyngeal cancer.Oncotarget · 2016Article
- A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and HPV-positive tumours of oropharyngeal cancer.European journal of cancer (Oxford, England : 1990) · 2015Article
- CpG-ODNs induced changes in cytokine/chemokines genes expression associated with suppression of infectious bronchitis virus replication in chicken lungs.Veterinary immunology and immunopathology · 2014Article
- Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses.Protein science : a publication of the Protein Society · 2014Review
- Is the inflammasome a potential therapeutic target in renal disease?BMC nephrology · 2014Article
- Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts.Annals of the rheumatic diseases · 2013Article
- Role of IL-18 in second-hand smoke-induced emphysema.American journal of respiratory cell and molecular biology · 2013Article
- Review
- CD8(+) T Cells Are Required For Glatiramer Acetate Therapy in Autoimmune Demyelinating Disease.PloS one · 2013Article
- Cytokines in the balance of protection and pathology during mycobacterial infections.Advances in experimental medicine and biology · 2013Review
- Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.Journal of autoimmunity · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IFN-gamma induces its immunoregulatory activities by activating genes mainly through the Jak-STAT signaling pathway. Here we show that what was considered to be intrinsic IFN-gamma activities depend largely on the basal level of NF-kappaB, which is maintained by constitutively expressed IL-1alpha. The IL-1 receptor antagonist and antibodies to IL-1alpha, but not to IL-1beta, inhibited the antiviral activity of IFN-gamma by 90%, whereas no inhibition of type I IFN activity was observed. Similarly, the induction of many genes by IFN-gamma, including HLA-DR, ICAM-1, IL-18BP, and genes mediating its antiviral activity, greatly depended on basal IL-1alpha. Furthermore, IFN-gamma induced serum IL-18 binding protein in wild-type mice but not in IL-1alpha/beta double-deficient mice. Thus, constitutively expressed IL-1alpha is critical for numerous IFN-gamma activities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.