ArticleProceedings of the National Academy of Sciences of the United States of America2007
Assisted reproductive technologies do not alter mutation frequency or spectrum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction.Genome research · 2026Article
- Increased rate ofbioRxiv : the preprint server for biology · 2025Article
- Intracytoplasmic sperm injection induces transgenerational abnormalities in mice.The Journal of clinical investigation · 2023Article
- The impact of paternal age on new mutations and disease in the next generation.Fertility and sterility · 2022Review
- Intracytoplasmic sperm injection in sturgeon species: A promising reproductive technology of selected genitors.Frontiers in veterinary science · 2022Article
- Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.Nature reviews. Genetics · 2018Review
- Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate.Stem cells and development · 2016Article
- Tertiary Epimutations - A Novel Aspect of Epigenetic Transgenerational Inheritance Promoting Genome Instability.PloS one · 2016Article
- Enhanced genetic integrity in mouse germ cells.Biology of reproduction · 2013Article
- Article
- Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies?Fertility and sterility · 2011Review
- Article
- Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Assessment of three generations of mice derived by ICSI using freeze-dried sperm.Zygote (Cambridge, England) · 2009Article
- Epigenetic regulation of genetic integrity is reprogrammed during cloning.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Further evidence of the safety of assisted reproductive technologies.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Assisted reproductive technologies (ARTs) have now contributed to the birth of >3 million babies worldwide, but concerns remain regarding the safety of these methods. We have used a transgenic mouse model to examine the effects of ARTs on the frequency and spectrum of point mutations in midgestation mouse fetuses produced by either natural reproduction or various methods of ART, including preimplantation culture, embryo transfer, in vitro fertilization, intracytoplasmic sperm injection, and round spermatid injection. Our results show that there is no significant difference in the frequency or spectrum of de novo point mutations found in naturally conceived fetuses and fetuses produced by in vitro fertilization, intracytoplasmic sperm injection, or round spermatid injection. These results, based on analyses of a transgenic mouse system, indicate that with respect to maintenance of genetic integrity, ARTs appear to be safe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.