ArticleProceedings of the National Academy of Sciences of the United States of America2007
Cytoskeletal dynamics of human erythrocyte.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed.
- Article
- Effects of the Mechanical Behaviors of Red Blood Cells on the Blood Flow.Advances in experimental medicine and biology · 2026Article
- Effect of intercellular collisions on red blood cell membrane damage.Scientific reports · 2025Article
- Mechanical adaptivity of red blood cell flickering to extrinsic membrane stiffening by the solid-like biosurfactant β-Aescin.Biophysical journal · 2025Article
- Dynamic mechanisms for membrane skeleton transitions.Journal of cell science · 2025Article
- Review
- Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hump-Nosed Pit Viper (Cells · 2024Article
- Viscoelasticity of diverse biological samples quantified by Acoustic Force Microrheology (AFMR).Communications biology · 2024Article
- Dynamic mechanisms for membrane skeleton transitions.bioRxiv : the preprint server for biology · 2024Article
- Lattice Boltzmann simulation of deformable fluid-filled bodies: progress and perspectives.Soft matter · 2024Review
- Hereditary Spherocytosis: Can Next-Generation Sequencing of the Five Most Frequently Affected Genes Replace Time-Consuming Functional Investigations?International journal of molecular sciences · 2023Article
- Tensile and Compressive Mechanical Behaviour of Human Blood Clot Analogues.Annals of biomedical engineering · 2023Article
- Increased red blood cell deformation in children and adolescents after SARS-CoV-2 infection.Scientific reports · 2023Article
- Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary.Biophysical journal · 2023Article
- Measuring cell deformation by microfluidics.Frontiers in bioengineering and biotechnology · 2023Review
- Cell-scale hemolysis evaluation of intervenient ventricular assist device based on dissipative particle dynamics.Frontiers in physiology · 2023Article
- The periodic axon membrane skeleton leads to Na nanodomains but does not impact action potentials.Biophysical journal · 2022Article
- Article
- A particle-based computational model to analyse remodelling of the red blood cell cytoskeleton during malaria infections.PLoS computational biology · 2022Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The human erythrocyte (red blood cell, RBC) demonstrates extraordinary ability to undergo reversible large deformation and fluidity. Such mechanical response cannot be consistently rationalized on the basis of fixed connectivity of the cell cytoskeleton that comprises the spectrin molecular network tethered to phospholipid membrane. Active topological remodeling of spectrin network has been postulated, although detailed models of such dynamic reorganization are presently unavailable. Here we present a coarse-grained cytoskeletal dynamics simulation with breakable protein associations to elucidate the roles of shear stress, specific chemical agents, and thermal fluctuations in cytoskeleton remodeling. We demonstrate a clear solid-to-fluid transition depending on the metabolic energy influx. The solid network's plastic deformation also manifests creep and yield regimes depending on the strain rate. This cytoskeletal dynamics model offers a means to resolve long-standing questions regarding the reference state used in RBC elasticity theory for determining the equilibrium shape and deformation response. In addition, the simulations offer mechanistic insights into the onset of plasticity and void percolation in cytoskeleton. These phenomena may have implication for RBC membrane loss and shape change in the context of hereditary hemolytic disorders such as spherocytosis and elliptocytosis.
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