ArticleProceedings of the National Academy of Sciences of the United States of America2007
Human herpesvirus 6A accelerates AIDS progression in macaques.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Prevalence of HHV-6 Detection Among People Living with HIV: A Systematic Review and Meta-Analysis.Viruses · 2025Pooled it
- Marmosets as models of infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival.Scientific reports · 2020Article
- First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia.HIV/AIDS (Auckland, N.Z.) · 2020Article
- Review
- Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Journal of translational medicine · 2018Review
- Advances in the Characterization of the T-Cell Response to Human Herpesvirus-6.Frontiers in immunology · 2018Review
- Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.Science immunology · 2017Article
- Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals.Journal of neurovirology · 2017Review
- Recent developments in animal models for human herpesvirus 6A and 6B.Current opinion in virology · 2014Review
- Discovery and biological characterization of two novel pig-tailed macaque homologs of HHV-6 and HHV-7.Virology · 2014Article
- Human herpesvirus 6A infection in CD46 transgenic mice: viral persistence in the brain and increased production of proinflammatory chemokines via Toll-like receptor 9.Journal of virology · 2014Article
- Classification of HHV-6A and HHV-6B as distinct viruses.Archives of virology · 2014Review
- Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication.Archives of virology · 2014Article
- Human herpesvirus 6A infection and immunopathogenesis in humanized Rag2⁻/⁻ γc⁻/⁻ mice.Journal of virology · 2013Article
- Article
- Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: a cross-sectional study.F1000Research · 2013Article
- Animal models for human herpesvirus 6 infection.Frontiers in microbiology · 2013Article
- Chromosomally integrated human herpesvirus 6: questions and answers.Reviews in medical virology · 2012Review
- The molecular biology of human herpesvirus-6 latency and telomere integration.Microbes and infection · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
Although HIV is the necessary and sufficient causative agent of AIDS, genetic and environmental factors markedly influence the pace of disease progression. Clinical and experimental evidence suggests that human herpesvirus 6A (HHV-6A), a cytopathic T-lymphotropic DNA virus, fosters the progression to AIDS in synergy with HIV-1. In this study, we investigated the effect of coinfection with HHV-6A on the progression of simian immunodeficiency virus (SIV) disease in pig-tailed macaques (Macaca nemestrina). Inoculation of HHV-6A resulted in a rapid appearance of plasma viremia associated with transient clinical manifestations and followed by antibody seroconversion, indicating that this primate species is susceptible to HHV-6A infection. Whereas animals infected with HHV-6A alone did not show any long-term clinical and immunological sequelae, a progressive loss of CD4(+) T cells was observed in all of the macaques inoculated with SIV. However, progression to full-blown AIDS was dramatically accelerated by coinfection with HHV-6A. Rapid disease development in dually infected animals was heralded by an early depletion of both CD4(+) and CD8(+) T cells. These results provide in vivo evidence that HHV-6A may act as a promoting factor in AIDS progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.