ArticleJournal of the Royal Society, Interface2007
The impact of prophylaxis of healthcare workers on influenza pandemic burden.
Article in Journal of the Royal Society, Interface, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Scarce-Resource Allocation and Patient Triage During the COVID-19 Pandemic: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2020Review
- The duty to care in an influenza pandemic: a qualitative study of Canadian public perspectives.Social science & medicine (1982) · 2012Article
- Protecting health care workers: a pandemic simulation based on Allegheny County.Influenza and other respiratory viruses · 2010Article
- A comparative evaluation of modelling strategies for the effect of treatment and host interactions on the spread of drug resistance.Journal of theoretical biology · 2009Article
- Managing public health crises: the role of models in pandemic preparedness.Influenza and other respiratory viruses · 2009Article
- Emergence of drug resistance: implications for antiviral control of pandemic influenza.Proceedings. Biological sciences · 2007Article
- Hydroxychloroquine for prophylaxis in COVID-19: Need to revisit dosing regimen.The Indian journal of medical researchArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several models have rationalized the use of antiviral drugs as an early control measure for delaying the progression and limiting the size of outbreaks during an influenza pandemic. However, the strategy for use of these drugs is still under debate. We evaluated the impact of prophylaxis of healthcare workers (HCWs) through a mathematical model that considers attack rates in a range of 25-35% in the general population and 25-50% among HCWs. Simulations and uncertainty analysis using the demographics of the province of Ontario, Canada show that increasing prophylaxis coverage of HCWs has little impact on reducing the reproduction number of disease transmission and may not prevent the occurrence of an outbreak if expected. However, it does enable a high level of treatment, which substantially reduces morbidity and mortality in the population as a whole. Therefore, prophylaxis of HCWs should be considered an important part of public health efforts for minimizing influenza pandemic burden and its socio-economic disruption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.