ReviewJournal of autoimmunity
The X and why of xenobiotics in primary biliary cirrhosis.
Review in Journal of autoimmunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.PloS one · 2012Pooled it
- New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage.World journal of gastroenterology · 2023Review
- Infliximab as a treatment option for patients with rheumatoid arthritis and primary biliary cirrhosis.Rheumatology international · 2015Review
- Mechanisms of tissue injury in autoimmune liver diseases.Seminars in immunopathology · 2014Review
- A Potential Link between Environmental Triggers and Autoimmunity.Autoimmune diseases · 2014Review
- Impact of microbes on autoimmune diseases.Archivum immunologiae et therapiae experimentalis · 2013Review
- Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis.Hepatology (Baltimore, Md.) · 2013Article
- Primary biliary cirrhosis in a genetically homogeneous population: disease associations and familial occurrence rates.BMC gastroenterology · 2012Article
- Primary biliary cirrhosis and Sjögren's syndrome: autoimmune epithelitis.Journal of autoimmunity · 2012Review
- Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: a case study and review of the literature.BMC gastroenterology · 2012Review
- Primary biliary cirrhosis and liver transplantation.Intractable & rare diseases research · 2012Review
- Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.Journal of autoimmunity · 2011Article
- Environmental pathways to autoimmune diseases: the cases of primary biliary cirrhosis and multiple sclerosis.Archives of medical science : AMS · 2011Article
- Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis.Hepatology (Baltimore, Md.) · 2011Article
- CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The autoimmunity of primary biliary cirrhosis and the clonal selection theory.Immunology and cell biology · 2011Review
- Immune-mediated bile duct injury: The case of primary biliary cirrhosis.World journal of gastrointestinal pathophysiology · 2010Article
- Mold and human health: separating the wheat from the chaff.Clinical reviews in allergy & immunology · 2010Review
- Toxicology of autoimmune diseases.Chemical research in toxicology · 2010Review
- Primary biliary cirrhosis.Seminars in immunopathology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Primary biliary cirrhosis (PBC) is a chronic autoimmune liver disease characterized by inflammation and destruction of intrahepatic biliary epithelial cells, ultimately leading to liver failure. The serological hallmark of PBC is the presence of high-titer antimitochondrial antibodies (AMA) against the inner lipoyl domain of E2 subunits of 2-oxo-acid dehydrogenase complexes, in particular the E2 component of the pyruvate dehydrogenase complex (PDC-E2). The initiating events triggering the autoimmune response are not yet identified but the hypothesis of molecular mimicry is a widely proposed mechanism for the development of autoimmunity in PBC. Several candidates, including bacteria and viruses, have been suggested as causative agents, but also environmental factors, such as chemical xenobiotics, have been implicated in the pathogenesis of primary biliary cirrhosis. In this review, we will discuss our current knowledge of the immunoreactivity of xenobiotically modified PDC peptide antigens. In addition, we will provide a working hypothesis how xenobiotic modification of antigens might occur that ultimately leads to the breaking of self-tolerance and the induction of PBC.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.