ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2007
Increased expression of HLA-DR and CD86 in nasal epithelial cells in allergic rhinitics: antigen presentation to T cells and up-regulation by diesel exhaust particles.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- IL-1Mediators of inflammation · 2023Review
- Air Pollution and Allergic Rhinitis: Role in Symptom Exacerbation and Strategies for Management.Journal of asthma and allergy · 2020Review
- Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis.Allergy, asthma & immunology research · 2018Review
- Antigen-presenting epithelial cells can play a pivotal role in airway allergy.The Journal of allergy and clinical immunology · 2016Article
- Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.The World Allergy Organization journal · 2015Article
- Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis.Experimental & molecular medicine · 2012Article
- Overview on the pathomechanisms of allergic rhinitis.Asia Pacific allergy · 2011Article
- Increased expression and role of thymic stromal lymphopoietin in nasal polyposis.Allergy, asthma & immunology research · 2011Article
- Up-regulation of Orai1 in murine allergic rhinitis.Histochemistry and cell biology · 2010Article
- Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation.Respiratory research · 2010Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA proportion of nasal epithelial cells (NEC) in patients with allergic rhinitis (AR) are known to express the major histocompatibility complex Class II molecule (HLA-DR).
objectiveWe hypothesized that NEC may play a role in antigen presentation to T cells. To elucidate the possible role of NEC in antigen presentation, we examined the expression of HLA-DR, CD80 and CD86 in NEC, their regulation by cytokines and the capacity of NEC to induce antigen-specific proliferation of T cells.
methodsWe examined the expression of HLA-DR, CD80 and CD86 in nasal epithelial scrapings of patients with seasonal allergic rhinitis (SAR) to Japanese cedar pollen pre-season and in-season, by immunohistochemistry. Next, we examined the effect of IL-1beta, TNF-alpha, (IFN-gamma), IL-4 alpha, IL-13 and diesel exhaust particles (DEP) on the HLA-DR, CD80 and CD86 expression in cultured nasal epithelial cells (CNEC), by flow cytometry. Further, we analysed the capacity of mite antigen (Der f II)-pulsed mitomycin-C-treated CNEC to induce proliferation of autologous T cells from patients with perennial allergic rhinitis.
resultsNEC constitutively expressed HLA-DR and CD86, but not CD80. The expression of HLA-DR and CD86 in NEC was significantly increased in-season, in patients with SAR as compared with that of pre-season. While IFN-gamma up-regulated the expression of HLA-DR, IL-1beta and TNF-alpha up-regulated the expression of CD86 in CNEC. Furthermore, in the presence of mite antigen, CNEC induced the proliferation of autologous peripheral blood T lymphocytes. Anti-CD86 and anti-HLA-DR monoclonal antibody but not anti-CD80 inhibited the epithelial cell-induced T cell proliferation. Stimulation with a combination of DEP and mite antigen significantly up-regulated HLA-DR and CD86 expression in CNEC.
conclusionsThese studies suggest that NEC in patients with AR may play a role in antigen presentation through the enhanced expression of HLA-DR and CD86. Furthermore, these results suggest the possibility that DEP may enhance the antigen-presenting function of CNEC.
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