Trial reportEnvironmental and molecular mutagenesis
Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV.
Trial report in Environmental and molecular mutagenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Cytogenetic changes in oral mucosal cells of human immunodeficiency virus-infected children and adolescents undergoing antiretroviral treatment.Revista da Associacao Medica Brasileira (1992) · 2023Trial
- Genotoxicity associated with hydroxyurea exposure in infants with sickle cell anemia: results from the BABY-HUG Phase III Clinical Trial.Pediatric blood & cancer · 2012Trial
- Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia.Mutation research · 2010Trial
- Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD.Journal of the American Academy of Child and Adolescent Psychiatry · 2008Trial
- Review
- A cross-sectional clinical study in women to investigate possible genotoxicity and hematological abnormalities related to the use of black cohosh botanical dietary supplements.Environmental and molecular mutagenesis · 2022Article
- Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation.Environmental and molecular mutagenesis · 2020Article
- Comparing genotoxic signatures in cord blood cells from neonates exposed in utero to zidovudine or tenofovir.AIDS (London, England) · 2015Article
- Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Exposure of Allium cepa root cells to zidovudine or nevirapine induces cytogenotoxic changes.PloS one · 2014Article
- Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age.The Journal of infectious diseases · 2013Article
- Antiretroviral therapy, pregnancy, and birth defects: a discussion on the updated data.HIV/AIDS (Auckland, N.Z.) · 2013Article
- An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents.Toxicology and applied pharmacology · 2012Article
- Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture.Mutation research · 2011Article
- Cardiac effects of antiretroviral therapy in HIV-negative infants born to HIV-positive mothers: NHLBI CHAART-1 (National Heart, Lung, and Blood Institute Cardiovascular Status of HAART Therapy in HIV-Exposed Infants and Children cohort study).Journal of the American College of Cardiology · 2011Article
- WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.Environmental and molecular mutagenesis · 2009Article
- Antiretroviral medications during pregnancy for therapy or prophylaxis.Current HIV/AIDS reports · 2009Review
- Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1.Environmental and molecular mutagenesis · 2009Article
- Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro.Mutation researchArticle
- Quantification of micronuclei in exfoliated cells of human immunodeficiency virus/AIDS-infected female patients.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Zidovudine-based antiretroviral therapies (ARTs) for treatment of HIV-infected pregnant women have markedly reduced mother-to-child transmission of the human immunodeficiency virus (HIV-1) from approximately 25% to <1%. However, zidovudine (ZDV; AZT), a nucleoside analogue, induces chromosomal damage, gene mutations, and cancer in animals following direct or transplacental exposure. To determine if chromosomal damage is induced by ZDV in infants exposed transplacentally, we evaluated micronucleated reticulocyte frequencies (%MN-RET) in 16 HIV-infected ART-treated mother-infant pairs. Thirteen women received prenatal ART containing ZDV; three received ART without ZDV. All infants received ZDV for 6 weeks postpartum. Venous blood was obtained from women at delivery and from infants at 1-3 days, 4-6 weeks, and 4-6 months of life; cord blood was collected immediately after delivery. Ten cord blood samples (controls) were obtained from infants of HIV-uninfected women who did not receive ART. %MN-RET was measured using a single laser 3-color flow cytometric system. Tenfold increases in %MN-RET were seen in women and infants who received ZDV-containing ART prenatally; no increases were detected in three women and infants who received prenatal ART without ZDV. Specifically, mean %MN-RET in cord blood of ZDV-exposed infants was 1.67 +/- 0.34 compared with 0.16 +/- 0.06 in non-ZDV ART-exposed infants (P = 0.006) and 0.12 +/- 0.02 in control cord bloods (P < 0.0001). %MN-RET in ZDV-exposed newborns decreased over the first 6 months of life to levels comparable to cord blood controls. These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.