ReviewPediatric nephrology (Berlin, Germany)2007
What's new in the aetiopathogenesis of vasculitis?
Review in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- The genetics of Henoch-Schönlein purpura: a systematic review and meta-analysis.Rheumatology international · 2013Pooled it
- Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch-Schönlein purpura: a meta-analysis.Journal of the renin-angiotensin-aldosterone system : JRAASPooled it
- LncRNAs in Kawasaki disease and Henoch-Schönlein purpura: mechanisms and clinical applications.Molecular and cellular biochemistry · 2024Review
- Detection of Angiogenic T Cells and Endothelial Progenitor Cells in Behçet Disease and Determination of Their Relationship with Disease Activity.Life (Basel, Switzerland) · 2023Article
- Vasculitis update: pathogenesis and biomarkers.Pediatric nephrology (Berlin, Germany) · 2018Review
- The association between MEFV gene polymorphisms and Henoch-Schönlein purpura, and additional SNP-SNP interactions in Chinese Han children.Rheumatology international · 2017Article
- Vasculitides and the Complement System: a Comprehensive Review.Clinical reviews in allergy & immunology · 2015Review
- Impaired function of endothelial progenitor cells in children with primary systemic vasculitis.Arthritis research & therapy · 2015Article
- MEFV E148Q polymorphism is associated with Henoch-Schönlein purpura in Chinese children.Pediatric nephrology (Berlin, Germany) · 2010Article
- Medium-size-vessel vasculitis.Pediatric nephrology (Berlin, Germany) · 2010Review
- Small vessel vasculitis.Pediatric nephrology (Berlin, Germany) · 2010Review
- Vasculitides associated with IgG antineutrophil cytoplasmic autoantibodies in childhood.Pediatric nephrology (Berlin, Germany) · 2010Review
- Systemic vasculitis in childhood.Current rheumatology reports · 2009Review
- Vasculitis in children.Best practice & research. Clinical rheumatology · 2009Review
- Infliximab for the treatment of intravenous immunoglobulin resistant Kawasaki disease complicated by coronary artery aneurysms: a case report.Pediatric rheumatology online journal · 2009Article
- Vasculitis in children and adolescents: clinical presentation, etiopathogenesis, and treatment.Paediatric drugs · 2009Review
- Atypical clinical course of Henoch-Schonlein purpura.Canadian family physician Medecin de famille canadien · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cause of the majority of childhood vasculitides is unknown although it is likely that a complex interaction between environmental factors and inherited host responses trigger the disease and determine the vasculitis phenotype. Epidemiological clues continue to implicate infectious triggers in Kawasaki syndrome (KS) and Henoch Schonlein purpura (HSP). Several genetic polymorphisms have now been described in KS and HSP which predispose to disease or predict disease severity. Anti-neutrophil cytoplasmic antibodies (ANCA) are now known to be directly involved in the pathogenesis of vascular injury in ANCA-associated vasculitides, although why some individuals develop ANCA in the first instance is not yet understood. Endothelial injury and repair are active areas of research in vasculitis. It is now possible to track endothelial injury non-invasively in children with vasculitis using surrogate markers of endothelial injury. The vasculogenic pathways involved in vascular repair following vasculitis, including endothelial progenitor cells, are beginning to be studied. It is anticipated that an improved understanding of the aetiopathogenesis of vasculitis in the young will ultimately shape future novel diagnostic and therapeutic approaches and will help us predict which children may develop premature arteriosclerosis in later life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.