ArticleAmerican journal of human genetics2007
Medical sequencing at the extremes of human body mass.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
139 citing papers in PubMed, 2 syntheses or guidelines pooled it, 0 citations in OpenAlex.
- Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.Human molecular genetics · 2013Pooled it
- A genome-wide association study of aging.Neurobiology of aging · 2011Pooled it
- Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes.Cardiovascular diabetology · 2024Article
- Rare variation in non-coding regions with evolutionary signatures contributes to autism spectrum disorder risk.Cell genomics · 2024Article
- Review
- Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.Journal of personalized medicine · 2023Review
- In Silico Examination of Single Nucleotide Missense Mutations inInternational journal of molecular sciences · 2023Article
- Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss.Frontiers in nutrition · 2023Article
- Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans.Human genetics · 2022Article
- Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses.Nature genetics · 2021Article
- Differential Signaling Profiles of MC4R Mutations with Three Different Ligands.International journal of molecular sciences · 2020Article
- Pathway analysis of rare variants for the clustered phenotypes by using hierarchical structured components analysis.BMC medical genomics · 2019Article
- Identifying Rare Variant Associations in Admixed Populations.Scientific reports · 2019Article
- CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.Science (New York, N.Y.) · 2019Article
- Identifying Multi-Omics Causers and Causal Pathways for Complex Traits.Frontiers in genetics · 2019Article
- Genetic variation in theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Comparative Genomics Approaches Accurately Predict Deleterious Variants in Plants.G3 (Bethesda, Md.) · 2018Article
- Genetic Risk Prediction for Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease: an Update.Current cardiology reports · 2018Review
- Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans.International journal of obesity (2005) · 2017Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
Body weight is a quantitative trait with significant heritability in humans. To identify potential genetic contributors to this phenotype, we resequenced the coding exons and splice junctions of 58 genes in 379 obese and 378 lean individuals. Our 96-Mb survey included 21 genes associated with monogenic forms of obesity in humans or mice, as well as 37 genes that function in body weight-related pathways. We found that the monogenic obesity-associated gene group was enriched for rare nonsynonymous variants unique to the obese population compared with the lean population. In addition, computational analysis predicted a greater fraction of deleterious variants within the obese cohort. Together, these data suggest that multiple rare alleles contribute to obesity in the population and provide a medical sequencing-based approach to detect them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.