ArticleAmerican journal of human genetics2007
Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression.Molecular psychiatry · 2013Pooled it
- Newly identified loci that influence lipid concentrations and risk of coronary artery disease.Nature genetics · 2008Pooled it
- Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease.Human genetics · 2008Trial
- The genetics of human performance.Nature reviews. Genetics · 2022Review
- Association of +138I/D and Lys198Asn Polymorphisms in the Endothelin-1 Gene with Early Onset of Coronary Artery Disease among the Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease.PloS one · 2020Article
- Analysis of causal effect of APOA5 variants on premature coronary artery disease.Annals of human genetics · 2018Article
- Lack of Evidence of the Role of APOA5 3'UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome.Diabetes & metabolism journal · 2018Article
- Article
- Population-based Study of Risk Polymorphisms Associated with Vascular Disorders and Dementia.Current genomics · 2017Article
- Genetic Risk Factors in Cerebrovascular Disorders and Cognitive Deterioration.Current genomics · 2017Article
- Association between theOncotarget · 2017Article
- Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia.Anatolian journal of cardiology · 2017Article
- Endothelin-1 gene polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2015Article
- The role of genetic risk factors in coronary artery disease.Current cardiology reports · 2014Review
- Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans.PLoS genetics · 2014Article
- Genetic variance in nitric oxide synthase and endothelin genes among children with and without endothelial dysfunction.Journal of translational medicine · 2013Article
- Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis?Journal of lipid research · 2012Review
- Arterial thrombus formation in cardiovascular disease.Nature reviews. Cardiology · 2011Review
- Genetic causes of high and low serum HDL-cholesterol.Journal of lipid research · 2010Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery disease (CAD) is a major health concern in both developed and developing countries. With a heritability estimated at ~50%, there is a strong rationale to better define the genetic contribution to CAD. This project involves the analysis of 884 individuals from 142 families (with average sibships of 5.7) as well as 558 case and control subjects from the Saguenay Lac St-Jean region of northeastern Quebec, with the use of 1,536 single-nucleotide polymorphisms (SNPs) in 103 candidate genes for CAD. By use of clusters of SNPs to generate multiallelic haplotypes at candidate loci for segregation studies within families, suggestive linkage for high-density lipoprotein (HDL) cholesterol is observed on chromosome 1p36.22. Furthermore, several associations that remain significant after Bonferroni correction are observed with lipoprotein-related traits as well as plasma concentrations of adiponectin. Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT). Whereas the other observed associations are described in the current literature, these two are new. Using an independent validation sample of 806 individuals, we confirm the EDN1 association (P<.005), whereas the LCAT association was nonsignificant (P=.12).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.