ArticleDigestive diseases and sciences2007
Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Intestinal stem cells promote crypt fission during postnatal growth of the small intestine.BMJ open gastroenterology · 2020Article
- Active β-Catenin Signaling in the Small Intestine of Humans During Infancy.Digestive diseases and sciences · 2019Article
- T-cell factor (TCF/LEF1) binding elements (TBEs) of FasL (Fas ligand or CD95 ligand) bind and cluster Fas (CD95) and form complexes with the TCF-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or cell activation.Cellular and molecular neurobiology · 2016Article
- Chemotherapy-induced gut toxicity and pain: involvement of TLRs.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- TCF4 Mediates the Maintenance of Neuropathic Pain Through Wnt/β-Catenin Signaling Following Peripheral Nerve Injury in Rats.Journal of molecular neuroscience : MN · 2015Article
- An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development.Frontiers in oncology · 2013Review
- Notch signaling promotes intestinal crypt fission in the infant rat.Digestive diseases and sciences · 2013Article
- Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells.Stem cells (Dayton, Ohio) · 2012Article
- The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition.The Journal of nutrition · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wnt/beta-catenin pathway has been proposed as promoting intestinal stem cell division. Wnt ligands activate cytoplasmic beta-catenin and increase nuclear translocation of beta-catenin that binds to the Tcf-4 transcription factor. The aim of this study was to investigate beta-catenin expression in the stem cell region of crypts during intestinal growth in rats. Litters of DAxPVG/c rats were humanely killed at 7, 14, 21, 35, and 72 days of life. beta-Catenin and Tcf-4 were quantified by immunoperoxidase staining and image analysis with cumulative signal analysis. Cytoplasmic and nuclear expression of beta-catenin peaked nearly 2-fold at day 14 (versus day 7) of life in the stem cell region of intestinal crypts. Tcf-4 nuclear expression peaked earlier at 7 days and was lower thereafter with age. We conclude that the Wnt/beta-catenin pathway is activated in the stem cell region of intestinal crypts during growth of the small intestine.
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