Trial reportEuropean journal of clinical nutrition2008
Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink.
Trial report in European journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Probiotics for the prevention of Clostridioides difficile-associated diarrhea in adults and children.The Cochrane database of systematic reviews · 2025Pooled it
- The efficacy of fermented foods in the treatment and management of diarrhoeal diseases: A systematic review and meta-analysis.Nutrition and health · 2023Pooled it
- Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults: A Meta-Analysis of Randomized Placebo-Controlled Trials.Journal of clinical gastroenterology · 2021Pooled it
- Efficacy of Single-Strain Probiotics Versus Multi-Strain Mixtures: Systematic Review of Strain and Disease Specificity.Digestive diseases and sciences · 2021Pooled it
- AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders.Gastroenterology · 2020Guideline
- Probiotics for the prevention of pediatric antibiotic-associated diarrhea.The Cochrane database of systematic reviews · 2019Pooled it
- A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands.BMC gastroenterology · 2018Guideline
- Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children.The Cochrane database of systematic reviews · 2017Pooled it
- Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis.Open medicine : a peer-reviewed, independent, open-access journal · 2013Pooled it
- Pooled it
- Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study.BMJ open · 2015Trial
- Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea.World journal of gastroenterology · 2014Trial
- Three Characterized Probiotics from Dairy Sources-Weissella confusa (ProY 5.1), Enterococcus lactis (ProY 5.3), and Leuconostoc lactis (RM 2.1)-Exhibit Potential for Antidiarrheal Effects.Probiotics and antimicrobial proteins · 2026Article
- Bifidobacteria in antibiotic-associated dysbiosis: restoring balance in the gut microbiome.World journal of microbiology & biotechnology · 2025Review
- Dairy associations for the targeted control of opportunistic Candida.World journal of microbiology & biotechnology · 2021Article
- Maternal probiotic milk intake during pregnancy and breastfeeding complications in the Norwegian Mother and Child Cohort Study.European journal of nutrition · 2020Article
- Probiotics in the next-generation sequencing era.Gut microbes · 2020Review
- Antidiarrheal Efficacy of Probiotic Bacteria in Castor Oil Induced Diarrheal Mice.Preventive nutrition and food science · 2018Article
- Infection ofFrontiers in immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the preventive effect of a milk drink fermented with multistrain probiotics on antibiotic associated diarrhoea (AAD).
designDouble-blind placebo controlled study.
settingUniversity Hospital of North Norway. SUBJECTS AND
methodsOf 853 patients treated with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a fermented milk drink containing LGG, La-5 and Bb-12 (n=46) or placebo with heat-killed bacteria (n=41), during a period of 14 days. A diary was recorded, and stool samples were collected for microbiological analyses.
resultsSixty-three patients completed the study according to the protocol; two patients (5.9%) in the treatment group and eight (27.6%) in the placebo group developed AAD (P=0.035). The relative risk of developing AAD was 0.21 (95% confidence interval: 0.05-0.93) when given probiotic milk drink.
conclusionA fermented multistrain probiotic milk drink may prevent four of five cases of AAD in adult hospitalized patients. SPONSORSHIP: TINE BA, Oslo, Norway.
Indexed as
Identifiers
17356555What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.