ArticleNucleic acids research2007
A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids.American journal of physiology. Endocrinology and metabolism · 2008Trial
- Seedless 3' pairing enables miR-17 family miRNAs to seize let-7 target sites.Nucleic acids research · 2026Article
- miRNA regulation in brain tissue space: the 3'UTR perspective.RNA (New York, N.Y.) · 2026Review
- Recent advances in the development and clinical application of miRNAs in infectious diseases.Non-coding RNA research · 2025Review
- A Comprehensive Review on the Importance of MiRNA-206 in the Animal Model and Human Diseases.Current neuropharmacology · 2024Review
- miRNA in Molecular Diagnostics.Bioengineering (Basel, Switzerland) · 2022Review
- Aerobic exercise modulates noncoding RNA network upstream of FNDC5 in the Gastrocnemius muscle of high-fat-diet-induced obese mice.Journal of physiology and biochemistry · 2021Article
- Detection of Circulating Serum microRNA/Protein Complexes in ASD Using Functionalized Chips for an Atomic Force Microscope.Molecules (Basel, Switzerland) · 2021Article
- MicroRNA-10 negatively regulates inflammation in diabetic kidney via targeting activation of the NLRP3 inflammasome.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Characterizing and Profiling microRNAs in Dogs Undergoing Induced Ischemic Brain Stroke After Middle Cerebral Artery Occlusion Under Fluoroscopic Guidance.Vascular health and risk management · 2021Article
- microRNAs in Neurodegeneration: Current Findings and Potential Impacts.Journal of Alzheimer's disease & Parkinsonism · 2018Article
- Targeting MicroRNA Function in Acute Pancreatitis.Frontiers in physiology · 2017Review
- MicroRNA-196a/b Mitigate Renal Fibrosis by Targeting TGF-β Receptor 2.Journal of the American Society of Nephrology : JASN · 2016Article
- Two-color imaging of microRNA with enzyme-free signal amplificationChemical science · 2016Article
- Differential microRNA Expression and Regulation in the Rat Model of Post-Infarction Heart Failure.PloS one · 2016Article
- Transcriptional Perturbations in Graft Rejection.Transplantation · 2015Article
- The characteristics of the porcine (Sus scrofa) liver miRNAome with the use of next generation sequencing.Journal of applied genetics · 2015Article
- Investigation of the Application of miR10b and miR135b in the Identification of Semen Stains.PloS one · 2015Article
- Article
- Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues.Scientific reports · 2014Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microarrays to examine the global expression levels of microRNAs (miRNAs) in a systematic in-parallel manner have become important tools to help unravel the functions of miRNAs and to understand their roles in RNA-based regulation and their implications in human diseases. We have established a novel miRNA-specific microarray platform that enables the simultaneous expression analysis of both known and predicted miRNAs obtained from human or mouse origin. Chemically modified 2'-O-(2-methoxyethyl)-(MOE) oligoribonucleotide probes were arrayed onto Evanescent Resonance (ER) microchips by robotic spotting. Supplementing the complementary probes against miRNAs with carefully designed mismatch controls allowed for accurate sequence-specific determination of miRNA expression profiles obtained from a panel of mouse tissues. This revealed new expression signatures of known miRNAs as well as of novel miRNAs previously predicted using bioinformatic methods. Systematic confirmation of the array data with northern blotting and, in particular, real-time PCR suggests that the described microarray platform is a powerful tool to analyze miRNA expression patterns with rapid throughput and high fidelity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.