ArticleThe Journal of biological chemistry2007
Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 54 citations in OpenAlex.
- Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review.Journal of neuroinflammation · 2024Review
- Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy.Cancers · 2023Review
- Nuclear-Mitochondrial Interactions.Biomolecules · 2022Review
- Mitochondrial DNA variation and cancer.Nature reviews. Cancer · 2021Review
- Decoding the rosetta stone of mitonuclear communication.Pharmacological research · 2020Review
- Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling.iScience · 2020Article
- Esophageal 3D organoids ofOncotarget · 2019Article
- Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control.Journal of clinical biochemistry and nutrition · 2019Review
- Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States.Cells · 2018Review
- Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype.PloS one · 2018Article
- hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction.PloS one · 2018Article
- Mitochondrial determinants of cancer health disparities.Seminars in cancer biology · 2017Review
- Mitochondrial stress-induced p53 attenuates HIF-1α activity by physical association and enhanced ubiquitination.Oncogene · 2017Article
- Calcineurin/nuclear factor-κB signaling mediates isoflurane-induced hippocampal neuroinflammation and subsequent cognitive impairment in aged rats.Molecular medicine reports · 2017Article
- Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA.Autophagy · 2016Article
- Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming.Oncogene · 2016Article
- Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene.Annals of the New York Academy of Sciences · 2016Article
- HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression.Cell discovery · 2016Article
- Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis.Genomics data · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have previously shown that disruption of mitochondrial membrane potential by depletion of mitochondrial DNA (mtDNA) or treatment with a mitochondrial ionophore, carbonyl cyanide m-chlorophenylhydrazone, initiates a stress signaling, which causes resistance to apoptosis, and induces invasive behavior in C2C12 myocytes and A549 cells. In the present study we show that calcineurin (Cn), activated as part of this stress signaling, plays an important role in increased glucose uptake and glycolysis. Here we report that, although both insulin and insulin-like growth factor-1 receptor levels (IR and IGF1R, respectively) are increased in response to mitochondrial stress, autophosphorylation of IGF1R was selectively increased suggesting a shift in receptor pathways. Using an approach with FK506, an inhibitor of Cn, and mRNA silencing by small interference RNA we show that mitochondrial stress-activated Cn is critical for increased GLUT 4 and IGF1R expression and activation. The importance of the IGF1R pathway in cell survival under mitochondrial stress is demonstrated by increased apoptosis either by IGF1R mRNA silencing or by treatment with IGF1R inhibitors (AG1024 and picropodophyllin). This study describes a novel mechanism of mitochondrial stress-induced metabolic shift involving Cn with implications in resistance to apoptosis and tumor proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.