ReviewPulmonary pharmacology & therapeutics2007
Encoding of the cough reflex.
Review in Pulmonary pharmacology & therapeutics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Inhaled corticosteroids for subacute and chronic cough in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Sulfolipid-1 fromJournal of neurophysiology · 2026Article
- Article
- A Neural Circuit Mechanism Controlling Breathing by Leptin in the Nucleus Tractus Solitarii.Neuroscience bulletin · 2022Article
- Antitussive effects of NaEuropean journal of pharmacology · 2021Article
- Pain at the Slaughterhouse in Ruminants with a Focus on the Neurobiology of Sensitisation.Animals : an open access journal from MDPI · 2021Review
- Article
- In Vivo Documentation of Stimulus Velocity Tuning of Mechanically Induced Reflex Cough.Physiological research · 2020Article
- Bradykinin sensitizes the cough reflex via a BRespiratory research · 2019Article
- Microinjection of kynurenic acid in the rostral nucleus of the tractus solitarius disrupts spatiotemporal aspects of mechanically induced tracheobronchial cough.Journal of neurophysiology · 2017Article
- Role of reactive oxygen species and TRP channels in the cough reflex.Cell calcium · 2016Review
- Airway protective mechanisms.Lung · 2014Review
- Cough: neurophysiology, methods of research, pharmacological therapy and phonoaudiology.International archives of otorhinolaryngology · 2012Review
- Perspective on the human cough reflex.Cough (London, England) · 2011Article
- Encoding of the cough reflex in anesthetized guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.European journal of pharmacology · 2010Article
- Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Central regulation of the cough reflex: therapeutic implications.Pulmonary pharmacology & therapeutics · 2009Review
- Intrinsic and synaptic long-term depression of NTS relay of nociceptin- and capsaicin-sensitive cardiopulmonary afferents hyperactivity.Pflugers Archiv : European journal of physiology · 2009Article
- Cough sensors. I. Physiological and pharmacological properties of the afferent nerves regulating cough.Handbook of experimental pharmacology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Coughing can be both voluntarily induced and involuntarily initiated by activation of vagal afferent nerves innervating the airways and lungs. Centrally, cough is regulated at the level of the brainstem through integration of vagal afferent nerve input by relay neurones in the nucleus tractus solitarius (nTS). Projections to and from the nTS add further complexity to cough regulation, as do the profound influences of psychological and social factors known to regulate cough. Peripherally, both neuronal and non-neuronal elements in the airways regulate the excitability of the vagal afferent nerve terminals regulating cough. These multiple levels of integration and encoding of the cough reflex may render this defensive respiratory response highly susceptible to modulation both by disease processes and through therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.