ArticleBMC neuroscience2007
A comparative genomics approach to identifying the plasticity transcriptome.
Article in BMC neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Nanopore sensing of individual transcription factors bound to DNA.Scientific reports · 2015Article
- Core and region-enriched networks of behaviorally regulated genes and the singing genome.Science (New York, N.Y.) · 2014Article
- Combined neuroimaging and gene expression analysis of the genetic basis of brain plasticity indicates across species homology.Human brain mapping · 2014Article
- Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
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- Epigenetic change detection and pattern recognition via Bayesian hierarchical hidden Markov models.Statistics in medicine · 2013Article
- Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression.Nature biotechnology · 2012Article
- cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?Psychopharmacology · 2011Article
- Article
- Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 region.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.Brain research · 2008Article
- Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes.BMC genomics · 2008Article
- Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus.Neural plasticity · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuronal activity regulates gene expression to control learning and memory, homeostasis of neuronal function, and pathological disease states such as epilepsy. A great deal of experimental evidence supports the involvement of two particular transcription factors in shaping the genomic response to neuronal activity and mediating plasticity: CREB and zif268 (egr-1, krox24, NGFI-A). The gene targets of these two transcription factors are of considerable interest, since they may help develop hypotheses about how neural activity is coupled to changes in neural function.
resultsWe have developed a computational approach for identifying binding sites for these transcription factors within the promoter regions of annotated genes in the mouse, rat, and human genomes. By combining a robust search algorithm to identify discrete binding sites, a comparison of targets across species, and an analysis of binding site locations within promoter regions, we have defined a group of candidate genes that are strong CREB- or zif268 targets and are thus regulated by neural activity. Our analysis revealed that CREB and zif268 share a disproportionate number of targets in common and that these common targets are dominated by transcription factors.
conclusionThese observations may enable a more detailed understanding of the regulatory networks that are induced by neural activity and contribute to the plasticity transcriptome. The target genes identified in this study will be a valuable resource for investigators who hope to define the functions of specific genes that underlie activity-dependent changes in neuronal properties.
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