ArticleFrontiers in zoology2007
Duplicated Hox genes in the spider Cupiennius salei.
Article in Frontiers in zoology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 82 citations in OpenAlex.
- Single-cell sequencing reveals potential novel insights into appendage-patterning and joint-development in a spider.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Assessing the Impact of Whole Genome Duplication on Gene Expression and Regulation During Arachnid Development.Genome biology and evolution · 2025Article
- Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Review
- A taxon-restricted duplicate of Iroquois3 is required for patterning the spider waist.PLoS biology · 2024Article
- The Development and Expansion of in vivo Germline Editing Technologies in Arthropods: Receptor-Mediated Ovary Transduction of Cargo (ReMOT Control) and Beyond.Integrative and comparative biology · 2023Review
- Evolution of the Spider Homeobox Gene Repertoire by Tandem and Whole Genome Duplication.Molecular biology and evolution · 2023Article
- Expression of posterior Hox genes and opisthosomal appendage development in a mygalomorph spider.Development genes and evolution · 2023Article
- Cas9-mediated gene editing in the black-legged tick,iScience · 2022Article
- Widespread retention of ohnologs in key developmental gene families following whole-genome duplication in arachnopulmonates.G3 (Bethesda, Md.) · 2021Article
- The Tetragnatha kauaiensis Genome Sheds Light on the Origins of Genomic Novelty in Spiders.Genome biology and evolution · 2021Article
- A chelicerate Wnt gene expression atlas: novel insights into the complexity of arthropod Wnt-patterning.EvoDevo · 2021Article
- Taxonomic Sampling and Rare Genomic Changes Overcome Long-Branch Attraction in the Phylogenetic Placement of Pseudoscorpions.Molecular biology and evolution · 2021Article
- A spider in motion: facets of sensory guidance.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Review
- Anterior Hox Genes and the Process of Cephalization.Frontiers in cell and developmental biology · 2021Review
- Developmental gene expression as a phylogenetic data class: support for the monophyly of Arachnopulmonata.Development genes and evolution · 2020Article
- Article
- The amphipod crustacean Parhyale hawaiensis: An emerging comparative model of arthropod development, evolution, and regeneration.Wiley interdisciplinary reviews. Developmental biology · 2019Review
- Homeobox Gene Duplication and Divergence in Arachnids.Molecular biology and evolution · 2018Article
- Recent progress and prospects for advancing arachnid genomics.Current opinion in insect science · 2018Review
- The house spider genome reveals an ancient whole-genome duplication during arachnid evolution.BMC biology · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHox genes are expressed in specific domains along the anterior posterior body axis and define the regional identity. In most animals these genes are organized in a single cluster in the genome and the order of the genes in the cluster is correlated with the anterior to posterior expression of the genes in the embryo. The conserved order of the various Hox gene orthologs in the cluster among most bilaterians implies that such a Hox cluster was present in their last common ancestor. Vertebrates are the only metazoans so far that have been shown to contain duplicated Hox clusters, while all other bilaterians seem to possess only a single cluster.
resultsWe here show that at least three Hox genes of the spider Cupiennius salei are present as two copies in this spider. In addition to the previously described duplicated Ultrabithorax gene, we here present sequence and expression data of a second Deformed gene, and of two Sex comb reduced genes. In addition, we describe the sequence and expression of the Cupiennius proboscipedia gene. The spider Cupiennius salei is the first chelicerate for which orthologs of all ten classes of arthropod Hox genes have been described. The posterior expression boundary of all anterior Hox genes is at the tagma border of the prosoma and opisthosoma, while the posterior boundary of the posterior Hox genes is at the posterior end of the embryo.
conclusionThe presence of at least three duplicated Hox genes points to a major duplication event in the lineage to this spider, perhaps even of the complete Hox cluster as has taken place in the lineage to the vertebrates. The combined data of all Cupiennius Hox genes reveal the existence of two distinct posterior expression boundaries that correspond to morphological tagmata boundaries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.