Trial reportJournal of psychiatry & neuroscience : JPN2007
Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion.
Trial report in Journal of psychiatry & neuroscience : JPN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 98 citations in OpenAlex.
- Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder.Journal of substance abuse treatment · 2017Trial
- Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment - a randomized double-blind placebo-controlled trial.Human psychopharmacology · 2016Trial
- Trial
- Effects of amphetamine on reactivity to emotional stimuli.Psychopharmacology · 2012Trial
- Trial
- The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.PloS one · 2012Trial
- Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Effect of D-amphetamine on inhibition and motor planning as a function of baseline performance.Psychopharmacology · 2010Trial
- Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males.Psychopharmacology · 2010Trial
- Are attention lapses related to d-amphetamine liking?Psychopharmacology · 2010Trial
- Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function.Human brain mapping · 2009Trial
- Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness.Psychopharmacology · 2008Trial
- The Incentive-Sensitization Theory of Addiction 30 Years On.Annual review of psychology · 2025Review
- Adult rat ultrasonic vocalizations and reward: Effects of propranolol and repeated cocaine administration.Journal of psychopharmacology (Oxford, England) · 2024Article
- Positive Affect: Nature and brain bases of liking and wanting.Current opinion in behavioral sciences · 2021Article
- Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing.International journal of tryptophan research : IJTR · 2020Review
- Effects of an acute bout of physical exercise on reward functioning in healthy adults.Physiology & behavior · 2018Article
- The Effects of Acute Dopamine Precursor Depletion on the Reinforcing Value of Exercise in Anorexia Nervosa.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMidbrain dopamine transmission is thought to regulate responses to rewarding drugs and drug-paired stimuli; however, the exact contribution, particularly in humans, remains unclear. In the present study, we tested whether decreasing dopamine synthesis, as produced by acute phenylalanine/tyrosine depletion (APTD), would alter responses to the stimulant drug, d-amphetamine.
methodsOn 3 separate days, 14 healthy men received d-amphetamine (0.3 mg/kg, given orally) plus a nutritionally balanced amino acid mixture, the phenylalanine/tyrosine-deficient mixture or the phenylalanine/tyrosine-deficient mixture followed by the immediate dopamine precursor, L-DOPA (Sinemet, 2 x 100 mg/25 mg). Responses to these treatments were assessed with visual analog scales, the Profile of Mood States, and a computerized Go/No-Go task.
resultsd-Amphetamine elicited its prototypical subjective effects, but these were not altered by APTD. In comparison, APTD significantly increased commission errors on the Go/No-Go task and did so uniquely in conditions where subjects were rewarded for making correct responses; this effect of APTD was prevented by L-DOPA.
conclusionsTogether these results support the hypothesis that, in healthy men, dopamine is not closely linked to euphorogenic effects of abused substances but does affect the salience of reward-related cues and the ability to respond to them preferentially.
Indexed as
Identifiers
17353942PMC1810580W1535680291What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.