ArticleDigestive diseases and sciences1992
Neurotensin prevents intestinal mucosal hypoplasia in rats fed an elemental diet.
Article in Digestive diseases and sciences, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.Oncotarget · 2015Article
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- Characterization of promoter elements regulating the expression of the human neurotensin/neuromedin N gene.The Journal of biological chemistry · 2011Article
- Intestinal adaptation after massive intestinal resection.Postgraduate medical journal · 2005Review
- Consequences of adrenalectomy on small intestine trophic parameters in aged and young rats: evidence of defective adaptation by aging and lack of corticoids.Digestive diseases and sciences · 2003Article
- Effect of aging on the adaptive and proliferative capacity of the small bowel.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2003Article
- Article
- Protective effect of enriched diet plus growth hormone administration on radiation-induced intestinal injury and on its evolutionary pattern in the rat.Digestive diseases and sciences · 1999Article
- Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM-43004C.Digestive diseases and sciences · 1999Article
- Fetal and neoplastic expression of the neurotensin gene in the human colon.Annals of surgery · 1996Article
- Characterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line.Molecular and cellular biology · 1995Article
- The neurotensin gene is a downstream target for Ras activation.The Journal of clinical investigation · 1995Article
- Bombesin stimulates mucosal growth in jejunal and ileal Thiry-Vella fistulas.Annals of surgery · 1995Article
- Expression of the neurotensin gene in fetal human liver and fibrolamellar carcinoma.Annals of surgery · 1994Article
- Developmental expression of the neurotensin gene in the rat liver.Annals of surgery · 1993Article
- Elemental diet-induced bacterial translocation can be hormonally modulated.Annals of surgery · 1993Article
- Neurotensin regulates growth of human pancreatic cancer.Annals of surgery · 1993Article
- Neurotensin expression and release in human colon cancers.Annals of surgery · 1992Article
- Neurotensin augments intestinal regeneration after small bowel resection in rats.Annals of surgery · 1992Article
- Glucagon-like peptide 2 is a potent growth factor for small intestine and colon.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Liquid elemental diets are associated with mucosal hypoplasia of both the small intestine and colon. Neurotensin, a tridecapeptide widely distributed in the gut, is trophic for the small intestine of rats fed a normal chow diet. The purpose of this study was to determine whether neurotensin could reverse the hypoplasia of intestinal mucosa that is associated with feeding a liquid elemental diet. Forty male Sprague-Dawley rats were randomized into five groups. Four groups were fed (for seven days) a glutamine-free liquid elemental diet. Subcutaneous injection of saline (control) or neurotensin (33, 100 or 300 micrograms/kg) were given to the groups of rats every 8 hr for seven days. Group five (Chow) received rat chow ad libitum for seven days. Rats were killed on day 8, and the proximal jejunum, distal ileum, and proximal colon removed. Mucosal weight, DNA, RNA, and protein contents were determined. Neurotensin (300 micrograms/kg) increased the cellularity of the small intestinal mucosa and reversed mucosal hypoplasia due to an elemental diet; a more pronounced effect was noted in the jejunum compared to the ileum. Neurotensin (33 and 100 micrograms/kg) increased mucosal DNA content in the jejunum but was not effective in reversing the hypoplasia. Neurotensin had no effect on growth of colonic mucosa. These results suggest that neurotensin may be an important trophic hormone for the small intestine. Administration of neurotensin may alleviate hypoplasia of the small bowel mucosa and maintain functional integrity of the gut during prolonged feeding of an elemental diet.
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