ReviewCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2007
A comprehensive view of sex-specific issues related to cardiovascular disease.
Review in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 124 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 4 syntheses or guidelines pooled it, 474 citations in OpenAlex.
- Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis.PloS one · 2017Pooled it
- Efficacy of cognitive behavioral therapy in reducing psychiatric symptoms in patients with implantable cardioverter defibrillator: an integrative review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Pooled it
- Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis.BMJ (Clinical research ed.) · 2013Pooled it
- Reporting on sex-based analysis in clinical trials of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker efficacy.The Canadian journal of cardiology · 2008Pooled it
- Relative Risk of Acute Myocardial Infarction in People with Schizophrenia and Bipolar Disorder: A Population-Based Cohort Study.PloS one · 2015Trial
- The effects of a tailored cardiac rehabilitation program on depressive symptoms in women: A randomized clinical trial.International journal of nursing studies · 2011Trial
- Rising Mortality from Sleep Apnea and Hypertension in U.S. Adults: A 23-Year Epidemiological Analysis And Impact of the COVID-19 Pandemic (2000-2023).Journal of epidemiology and global health · 2026Article
- Association between visceral adipose tissue measured by deep neural network architecture and chronic kidney disease.Scientific reports · 2026Article
- Cardiovascular sex differences and associated factors among adult population in Somaliland using insights from Somaliland demography and health survey.American heart journal plus : cardiology research and practice · 2026Review
- Cardiovascular Disease and Risk Factors in Women in Latin America and the Caribbean.Arquivos brasileiros de cardiologia · 2026Article
- Development and validation of an integrated preclinical model mimicking cardiometabolic risk in postmenopausal female rats.Scientific reports · 2025Article
- Nationwide Trends in Demographics, Comorbidities, and Mortality Among Elderly Patients with Heart Failure with Preserved Ejection Fraction Hospitalized with Cardiac Arrest.Journal of personalized medicine · 2025Article
- Sex Modifies Metabolic Pathways Associated with Lipids in Untargeted Metabolomics: The Coronary Artery Risk Development in Young Adults (CARDIA) Study, 2005-2006.Metabolites · 2025Article
- Healthcare providers' awareness and management of cardiovascular risks in women with hypertensive disorders of pregnancy and gestational diabetes.Archives of gynecology and obstetrics · 2025Article
- Trajectories of plant-based dietary patterns and their sex-specific associations with cardiometabolic health among young Australian adults.The international journal of behavioral nutrition and physical activity · 2025Article
- Global Burden of Cardiovascular Disease Attributable to Sugar-Sweetened Beverages in Middle-Aged Adults: An Age-Period-Cohort Modelling Study.Journal of the American Heart Association · 2025Article
- Population and Co-Occurrence Characteristics of Diagnoses and Comorbidities in Coronary Artery Disease Patients: A Case Study from a Hospital in Guangxi, China.Bioengineering (Basel, Switzerland) · 2024Article
- Visceral-to-peripheral adiposity ratio: a critical determinant of sex and ethnic differences in cardiovascular risks among Asian Indians and African Creoles in Mauritius.International journal of obesity (2005) · 2024Article
- Review
- Role of G-protein coupled receptors in cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) is the leading cause of mortality in women. In fact, CVD is responsible for a third of all deaths of women worldwide and half of all deaths of women over 50 years of age in developing countries. The prevalence of CVD risk factor precursors is increasing in children. Retrospective analyses suggest that there are some clinically relevant differences between women and men in terms of prevalence, presentation, management and outcomes of the disease, but little is known about why CVD affects women and men differently. For instance, women with diabetes have a significantly higher CVD mortality rate than men with diabetes. Similarly, women with atrial fibrillation are at greater risk of stroke than men with atrial fibrillation. Historically, women have been underrepresented in clinical trials. The lack of good trial evidence concerning sex-specific outcomes has led to assumptions about CVD treatment in women, which in turn may have resulted in inadequate diagnoses and suboptimal management, greatly affecting outcomes. This knowledge gap may also explain why cardiovascular health in women is not improving as fast as that of men. Over the last decades, mortality rates in men have steadily declined, while those in women remained stable. It is also becoming increasingly evident that gender differences in cultural, behavioural, psychosocial and socioeconomic status are responsible, to various degrees, for the observed differences between women and men. However, the interaction between sex-and gender-related factors and CVD outcomes in women remains largely unknown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.