ArticleThe Journal of experimental medicine2007
Lack of Foxp3 function and expression in the thymic epithelium.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 69 citations in OpenAlex.
- Topoisomerase 1 is required for the development and function of thymus.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- An essential role for miR-15/16 in Treg suppression and restriction of proliferation.Cell reports · 2023Article
- Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.The Journal of clinical investigation · 2023Article
- Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes.iScience · 2023Article
- Selective reprogramming of regulatory T cells in solid tumors can strongly enhance or inhibit tumor growth.Frontiers in immunology · 2023Article
- Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation.Cell reports · 2021Article
- Lymph Node Stromal Cell-Intrinsic MHC Class II Expression Promotes MHC Class I-Restricted CD8 T Cell Lineage Conversion to Regulatory CD4 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data.Nature communications · 2021Article
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- Treg-specific deletion of NKAP results in severe, systemic autoimmunity due to peripheral loss of Tregs.Journal of autoimmunity · 2018Article
- Premature expression of Foxp3 in double-negative thymocytes.PloS one · 2015Article
- Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.Immunity, inflammation and disease · 2014Article
- Foxp3 expression in T regulatory cells and other cell lineages.Cancer immunology, immunotherapy : CII · 2014Review
- Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.Immunity · 2014Article
- FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis.Oncotarget · 2014Article
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- Article
- Immunomodulation for gastrointestinal infections.Expert review of anti-infective therapy · 2012Review
- Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation.PloS one · 2012Article
- Regulatory T cells: mechanisms of differentiation and function.Annual review of immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foxp3 is essential for the commitment of differentiating thymocytes to the regulatory CD4(+) T (T reg) cell lineage. In humans and mice with a genetic Foxp3 deficiency, absence of this critical T reg cell population was suggested to be responsible for the severe autoimmune lesions. Recently, it has been proposed that in addition to T reg cells, Foxp3 is also expressed in thymic epithelial cells where it is involved in regulation of early thymocyte differentiation and is required to prevent autoimmunity. Here, we used genetic tools to demonstrate that the thymic epithelium does not express Foxp3. Furthermore, we formally showed that genetic abatement of Foxp3 in the hematopoietic compartment, i.e. in T cells, is both necessary and sufficient to induce the autoimmune lesions associated with Foxp3 loss. In contrast, deletion of a conditional Foxp3 allele in thymic epithelial cells did not result in detectable changes in thymocyte differentiation or pathology. Therefore, in mice the only known role for Foxp3 remains promotion of T reg cell differentiation within the T cell lineage, whereas there is no role for Foxp3 in thymic epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.