ArticleThe Journal of cell biology2007
The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 124 citations in OpenAlex.
- Dynamic integration of CXCL8 or CCL20 signaling with IL-15 or IL-32α reprograms human T-cell functional plasticity.Frontiers in immunology · 2026Article
- A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway.Development (Cambridge, England) · 2025Article
- ARAP1 fine-tunes F-actin polymerization level in lymphocytes through RhoA inhibition.Frontiers in immunology · 2025Article
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- Cell polarity regulators, multifunctional organizers of lymphocyte activation and function.Biomedical journal · 2022Review
- Cytoskeleton Dynamics in Peripheral T Cell Lymphomas: An Intricate Network Sustaining Lymphomagenesis.Frontiers in oncology · 2021Review
- The Tec Kinase Itk Integrates Naïve T Cell Migration andFrontiers in immunology · 2021Article
- The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center.Small GTPases · 2020Article
- CDC-42 Interactions with Par Proteins Are Critical for Proper Patterning in Polarization.Cells · 2020Article
- 4E-BP1Cancer management and research · 2020Article
- Ras and Rap1: A tale of two GTPases.Seminars in cancer biology · 2019Review
- Structural basis of inactivation of Ras and Rap1 small GTPases by Ras/Rap1-specific endopeptidase from the sepsis-causing pathogenThe Journal of biological chemistry · 2018Article
- The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling.Frontiers in immunology · 2018Article
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- Roles of Rap1 signaling in tumor cell migration and invasion.Cancer biology & medicine · 2017Article
- β-Arrestin 1-dependent regulation of Rap2 is required for fMLP-stimulated chemotaxis in neutrophil-like HL-60 cells.Journal of leukocyte biology · 2017Article
- Correction to Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.Biochemistry · 2016Article
- Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.Biochemistry · 2016Article
- Microenvironmental Control of High-Speed Interstitial T Cell Migration in the Lymph Node.Frontiers in immunology · 2016Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell polarization is required for virtually all functions of T cells, including transendothelial migration in response to chemokines. However, the molecular pathways that establish T cell polarity are poorly understood. We show that the activation of the partitioning defective (Par) polarity complex is a key event during Rap1- and chemokine-induced T cell polarization. Intracellular localization and activation of the Par complex are initiated by Rap1 and require Cdc42 activity. The Rac activator Tiam1 associates with both Rap1 and components of the Par complex, and thereby may function to connect the Par polarity complex to Rap1 and to regulate the Rac-mediated actin remodelling required for T cell polarization. Consistent with these findings, Tiam1-deficient T cells are impaired in Rap1- and chemokine-induced polarization and chemotaxis. Our studies implicate Tiam1 and the Par polarity complex in polarization of T cells, and provide a mechanism by which chemokines and Rap1 regulate T cell polarization and chemotaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.